Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19.
Proc Natl Acad Sci U S A
; 119(34): e2201541119, 2022 08 23.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1984598
ABSTRACT
Whereas pathogen-specific T and B cells are a primary focus of interest during infectious disease, we have used COVID-19 to ask whether their emergence comes at a cost of broader B cell and T cell repertoire disruption. We applied a genomic DNA-based approach to concurrently study the immunoglobulin-heavy (IGH) and T cell receptor (TCR) ß and δ chain loci of 95 individuals. Our approach detected anticipated repertoire focusing for the IGH repertoire, including expansions of clusters of related sequences temporally aligned with SARS-CoV-2-specific seroconversion, and enrichment of some shared SARS-CoV-2-associated sequences. No significant age-related or disease severity-related deficiencies were noted for the IGH repertoire. By contrast, whereas focusing occurred at the TCRß and TCRδ loci, including some TCRß sequence-sharing, disruptive repertoire narrowing was almost entirely limited to many patients aged older than 50 y. By temporarily reducing T cell diversity and by risking expansions of nonbeneficial T cells, these traits may constitute an age-related risk factor for COVID-19, including a vulnerability to new variants for which T cells may provide key protection.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Receptores de Antígenos de Linfocitos T
/
Receptores de Antígenos de Linfocitos T alfa-beta
/
Cadenas Pesadas de Inmunoglobulina
/
Inmunidad Adaptativa
/
SARS-CoV-2
/
COVID-19
Tipo de estudio:
Estudio pronóstico
Tópicos:
Variantes
Límite:
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Proc Natl Acad Sci U S A
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
Pnas.2201541119
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