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Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19.
Joseph, Magdalene; Wu, Yin; Dannebaum, Richard; Rubelt, Florian; Zlatareva, Iva; Lorenc, Anna; Du, Zhipei Gracie; Davies, Daniel; Kyle-Cezar, Fernanda; Das, Abhishek; Gee, Sarah; Seow, Jeffrey; Graham, Carl; Telman, Dilduz; Bermejo, Clara; Lin, Hai; Asgharian, Hosseinali; Laing, Adam G; Del Molino Del Barrio, Irene; Monin, Leticia; Muñoz-Ruiz, Miguel; McKenzie, Duncan R; Hayday, Thomas S; Francos-Quijorna, Isaac; Kamdar, Shraddha; Davis, Richard; Sofra, Vasiliki; Cano, Florencia; Theodoridis, Efstathios; Martinez, Lauren; Merrick, Blair; Bisnauthsing, Karen; Brooks, Kate; Edgeworth, Jonathan; Cason, John; Mant, Christine; Doores, Katie J; Vantourout, Pierre; Luong, Khai; Berka, Jan; Hayday, Adrian C.
  • Joseph M; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Wu Y; Immunosurveillance Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
  • Dannebaum R; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Rubelt F; Immunosurveillance Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
  • Zlatareva I; Breast Cancer Now Research Unit, King's College London, London, SE1 9RT, United Kingdom.
  • Lorenc A; Department of Medical Oncology, Guy's and St. Thomas' NHS Foundation Trust, London, SE1 9RT, United Kingdom.
  • Du ZG; UCL Cancer Institute, University College London, London, WC1E 6DD, United Kingdom.
  • Davies D; Roche Diagnostics Solutions, Pleasanton, CA, 94588.
  • Kyle-Cezar F; Roche Diagnostics Solutions, Pleasanton, CA, 94588.
  • Das A; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Gee S; Immunosurveillance Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
  • Seow J; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Graham C; Roche Diagnostics Solutions, Pleasanton, CA, 94588.
  • Telman D; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Bermejo C; Department of Plastic and Reconstructive Surgery, Royal Free NHS Foundation Trust, London, NW3 2QG, United Kingdom.
  • Lin H; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Asgharian H; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Laing AG; London School of Hygiene & Tropical Medicine, London, WC1E 7HT, United Kingdom.
  • Del Molino Del Barrio I; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Monin L; Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Muñoz-Ruiz M; Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • McKenzie DR; Roche Diagnostics Solutions, Pleasanton, CA, 94588.
  • Hayday TS; Roche Diagnostics Solutions, Pleasanton, CA, 94588.
  • Francos-Quijorna I; Roche Diagnostics Solutions, Pleasanton, CA, 94588.
  • Kamdar S; Roche Diagnostics Solutions, Pleasanton, CA, 94588.
  • Davis R; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Sofra V; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Cano F; UCL Cancer Institute, University College London, London, WC1E 6DD, United Kingdom.
  • Theodoridis E; Immunosurveillance Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
  • Martinez L; Immunosurveillance Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
  • Merrick B; Immunosurveillance Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
  • Bisnauthsing K; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Brooks K; Regeneration Group, Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AB, United Kingdom.
  • Edgeworth J; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Cason J; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Mant C; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Doores KJ; Immunosurveillance Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
  • Vantourout P; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, United Kingdom.
  • Luong K; Research and Development Department, Guy's and St. Thomas' NHS Foundation Trust, London, SE1 7EH, United Kingdom.
  • Berka J; Centre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, United Kingdom.
  • Hayday AC; Research and Development Department, Guy's and St. Thomas' NHS Foundation Trust, London, SE1 7EH, United Kingdom.
Proc Natl Acad Sci U S A ; 119(34): e2201541119, 2022 08 23.
Artículo en Inglés | MEDLINE | ID: covidwho-1984598
ABSTRACT
Whereas pathogen-specific T and B cells are a primary focus of interest during infectious disease, we have used COVID-19 to ask whether their emergence comes at a cost of broader B cell and T cell repertoire disruption. We applied a genomic DNA-based approach to concurrently study the immunoglobulin-heavy (IGH) and T cell receptor (TCR) ß and δ chain loci of 95 individuals. Our approach detected anticipated repertoire focusing for the IGH repertoire, including expansions of clusters of related sequences temporally aligned with SARS-CoV-2-specific seroconversion, and enrichment of some shared SARS-CoV-2-associated sequences. No significant age-related or disease severity-related deficiencies were noted for the IGH repertoire. By contrast, whereas focusing occurred at the TCRß and TCRδ loci, including some TCRß sequence-sharing, disruptive repertoire narrowing was almost entirely limited to many patients aged older than 50 y. By temporarily reducing T cell diversity and by risking expansions of nonbeneficial T cells, these traits may constitute an age-related risk factor for COVID-19, including a vulnerability to new variants for which T cells may provide key protection.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Receptores de Antígenos de Linfocitos T / Receptores de Antígenos de Linfocitos T alfa-beta / Cadenas Pesadas de Inmunoglobulina / Inmunidad Adaptativa / SARS-CoV-2 / COVID-19 Tipo de estudio: Estudio pronóstico Tópicos: Variantes Límite: Anciano / Humanos Idioma: Inglés Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Artículo País de afiliación: Pnas.2201541119

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Receptores de Antígenos de Linfocitos T / Receptores de Antígenos de Linfocitos T alfa-beta / Cadenas Pesadas de Inmunoglobulina / Inmunidad Adaptativa / SARS-CoV-2 / COVID-19 Tipo de estudio: Estudio pronóstico Tópicos: Variantes Límite: Anciano / Humanos Idioma: Inglés Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Artículo País de afiliación: Pnas.2201541119