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Thyroid Function and COVID-19 Susceptibility and Its Severity: A Two-Sample Mendelian Randomization Study.
Zhang, Zhihao; Fang, Tian; Chen, Lanlan; Qiu, Binxu; Lv, Yonggang.
  • Zhang Z; Department of Thyroid Breast Surgery, Xi'an NO.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, Shaanxi, 710018, P.R. China.
  • Fang T; Department of Medical Oncology, Cancer Center, West China Hospital of Sichuan University, Chengdu, China.
  • Chen L; Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin Province, China.
  • Qiu B; Department of Gastrocolorectal and Surgery, The First Hospital of Jilin University, Changchun, Jilin Province, China.
  • Lv Y; Department of Thyroid Breast Surgery, Xi'an NO.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, Shaanxi, 710018, P.R. China.
Endocrinology ; 163(11)2022 10 11.
Artículo en Inglés | MEDLINE | ID: covidwho-2021399
ABSTRACT
Several observational studies have confirmed the relationship between thyroid hormones and coronavirus disease 2019 (COVID-19), but this correlation remains controversial. We performed a two-sample Mendelian randomization (MR) analysis based on the largest publicly available summary datasets. Summary statistics with 49 269 individuals for free thyroxine (FT4) and 54 288 for thyroid stimulating hormone (TSH) were used as exposure instruments. Genome-wide association studies of susceptibility (cases = 38 984; controls = 1 644 784), hospitalization (cases 9986 = controls = 1 877 672), and very severe disease (cases = 5101; controls = 1 383 241) of COVID-19 were used as the outcome. We used the inverse-variance weighted (IVW) method as the primary analysis, and utilized MR-Egger regression, weighted median, and robust adjusted profile score (RAPS) for sensitivity analysis. Genetic predisposition to higher serum levels of FT4 within the normal range was negatively associated with the risk of COVID-19 hospitalization (odds ratio [OR] = 0.818; 95% CI, 0.718-0.932; P = 2.6 × 10-3) and very severe disease (OR = 0.758; 95% CI, 0.626-0.923; P = 5.8 × 10-3), but not susceptibility. There is no evidence that genetically predicted circulating TSH levels are associated with COVID-19 susceptibility and severity risk. Neither apparent pleiotropy nor heterogeneity were detected in the sensitivity analysis. In summary, we found that higher FT4 levels may reduce the risk of COVID-19 severity, suggesting that thyroid function testing may be required for patients with COVID-19.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Glándula Tiroides / COVID-19 Tipo de estudio: Estudios diagnósticos / Estudio experimental / Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Año: 2022 Tipo del documento: Artículo

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Glándula Tiroides / COVID-19 Tipo de estudio: Estudios diagnósticos / Estudio experimental / Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Año: 2022 Tipo del documento: Artículo