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Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine Candidates.
Yu, Shouzhi; He, Yao; Ji, Wenheng; Yang, Rong; Zhao, Yuxiu; Li, Yan; Liu, Yingwei; Ding, Ling; Ma, Meng; Wang, Hui; Yang, Xiaoming.
  • Yu S; Beijing Institute of Biological Products Company Limited, Beijing 100176, China.
  • He Y; Beijing Institute of Biological Products Company Limited, Beijing 100176, China.
  • Ji W; Beijing Institute of Biological Products Company Limited, Beijing 100176, China.
  • Yang R; Beijing Institute of Biological Products Company Limited, Beijing 100176, China.
  • Zhao Y; Beijing Institute of Biological Products Company Limited, Beijing 100176, China.
  • Li Y; Beijing Institute of Biological Products Company Limited, Beijing 100176, China.
  • Liu Y; Beijing Institute of Biological Products Company Limited, Beijing 100176, China.
  • Ding L; Beijing Institute of Biological Products Company Limited, Beijing 100176, China.
  • Ma M; Beijing Institute of Biological Products Company Limited, Beijing 100176, China.
  • Wang H; Beijing Institute of Biological Products Company Limited, Beijing 100176, China.
  • Yang X; China National Biotec Group Company Limited, Beijing 100024, China.
Int J Mol Sci ; 23(18)2022 Sep 13.
Artículo en Inglés | MEDLINE | ID: covidwho-2032987
ABSTRACT
Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, the virus has been mutating continuously, resulting in the continuous emergence of variants and creating challenges for epidemic prevention and control. Here, we immunized mice with different vaccine candidates, revealing the immune, protein, and metabolomic changes that take place in vaccines composed of different variants. We found that the prototype strain and Delta- and Omicron-variant inactivated vaccine candidates could all induce a high level of neutralizing antibodies and cellular immunity responses in mice. Next, we found that the metabolic and protein profiles were changed, showing a positive association with immune responses, and the level of the change was distinct in different inactivated vaccines, indicating that amino acid variations could affect metabolomics and proteomics. Our findings reveal differences between vaccines at the metabolomic and proteomic levels. These insights provide a novel direction for the immune evaluation of vaccines and could be used to guide novel strategies for vaccine design.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Vacunas Virales / COVID-19 Tipo de estudio: Estudio experimental Tópicos: Vacunas / Variantes Límite: Animales / Humanos Idioma: Inglés Año: 2022 Tipo del documento: Artículo País de afiliación: Ijms231810644

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Vacunas Virales / COVID-19 Tipo de estudio: Estudio experimental Tópicos: Vacunas / Variantes Límite: Animales / Humanos Idioma: Inglés Año: 2022 Tipo del documento: Artículo País de afiliación: Ijms231810644