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Lupus anticoagulant-hypoprothrombinemia syndrome with severe bleeding diathesis after coronavirus disease 2019: a case report.
Brblic, Tomislav; Brcic, Klara; Margetic, Sandra; Carzavec, Dubravka; Gacina, Petar; Bogdanic, Nikolina.
  • Brblic T; Tomislav Brblic, Department of Hematology, Sestre Milosrdnice University, Hospital Center, 10000 Zagreb, Croatia, tbrblic91@gmail.com.
Croat Med J ; 63(5): 490-494, 2022 Oct 31.
Artículo en Inglés | MEDLINE | ID: covidwho-2092263
ABSTRACT
Acquired antibodies against factor II (prothrombin) are rare and most commonly associated with severe liver disease or vitamin K antagonist treatment. In very rare cases, these antibodies and associated hypoprothrombinemia are found in patients with lupus anticoagulant (LAC), an antiphospholipid antibody that inhibits phospholipid-dependent coagulation tests. This uncommon entity, called lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS), may cause both severe, life-threatening bleeding and a predisposition to thrombosis. Coronavirus disease 2019 (COVID-19) is associated with a variety of coagulation abnormalities and an increased risk of thrombosis. Bleeding may occur, but it is less common than thromboembolism and has mostly been described in association with the severity of the disease and anticoagulation treatment in hospitalized patients, rarely in the post-acute phase of the disease. We report on a case of an 80-year-old man who developed LAHPS with prothrombin antibodies and severe bleeding after COVID-19.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Síndrome Antifosfolípido / COVID-19 / Hipoprotrombinemias Tipo de estudio: Reporte de caso / Estudio pronóstico Tópicos: Covid persistente Límite: Humanos / Masculino Idioma: Inglés Revista: Croat Med J Asunto de la revista: Medicina Año: 2022 Tipo del documento: Artículo

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Síndrome Antifosfolípido / COVID-19 / Hipoprotrombinemias Tipo de estudio: Reporte de caso / Estudio pronóstico Tópicos: Covid persistente Límite: Humanos / Masculino Idioma: Inglés Revista: Croat Med J Asunto de la revista: Medicina Año: 2022 Tipo del documento: Artículo