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Decrease in serum levels of autotaxin in COVID-19 patients.
Shimura, Takuya; Kurano, Makoto; Okamoto, Koh; Jubishi, Daisuke; Hashimoto, Hideki; Kano, Kuniyuki; Igarashi, Koji; Shimamoto, Satoshi; Aoki, Junken; Moriya, Kyoji; Yatomi, Yutaka.
  • Shimura T; Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.
  • Kurano M; Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.
  • Okamoto K; Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Jubishi D; Department of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.
  • Hashimoto H; Department of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.
  • Kano K; Department of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.
  • Igarashi K; Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • Shimamoto S; Bioscience Division, TOSOH Corporation, Kanagawa, Japan.
  • Aoki J; Bioscience Division, TOSOH Corporation, Kanagawa, Japan.
  • Moriya K; Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • Yatomi Y; Department of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.
Ann Med ; 54(1): 3189-3200, 2022 12.
Artículo en Inglés | MEDLINE | ID: covidwho-2106905
ABSTRACT

INTRODUCTION:

In order to identify therapeutic targets in Coronavirus disease 2019 (COVID-19), it is important to identify molecules involved in the biological responses that are modulated in COVID-19. Lysophosphatidic acids (LPAs) are involved in the pulmonary inflammation and fibrosis are one of the candidate molecules. The aim of this study was to evaluate the association between the serum levels of autotaxin (ATX), which are enzymes involved in the synthesis of lysophosphatidic acids. MATERIAL AND

METHODS:

We enrolled 134 subjects with COVID-19 and 58 normal healthy subjects for the study. We measured serum ATX levels longitudinally in COVID-19 patients and investigated the time course and the association with severity and clinical parameters.

RESULTS:

The serum ATX levels were reduced in all patients with COVID-19, irrespective of the disease severity, and were negatively associated with the serum CRP, D-dimer, and anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody levels.

DISCUSSION:

Considering the biological properties of LPAs in the pulmonary inflammation and fibrosis, modulation of ATX might be compensatory biological responses to suppress immunological overreaction especially in the lung, which is an important underlying mechanism for the mortality of the disease.

CONCLUSIONS:

COVID-19 patients showed a decrease in the serum levels of ATX, irrespective of the disease severity. Key MessagesAutotaxin (ATX) is an enzyme involved in the synthesis of lysophosphatidic acid (LPA), which has been reported to be involved in pulmonary inflammation and fibrosis. Patients with COVID-19 show decrease in the serum levels of ATX. Modulation of ATX might be compensatory biological responses to suppress immunological overreaction.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Hidrolasas Diéster Fosfóricas / COVID-19 Tipo de estudio: Estudio experimental / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Ann Med Asunto de la revista: Medicina Año: 2022 Tipo del documento: Artículo País de afiliación: 07853890.2022.2143554

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Hidrolasas Diéster Fosfóricas / COVID-19 Tipo de estudio: Estudio experimental / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Ann Med Asunto de la revista: Medicina Año: 2022 Tipo del documento: Artículo País de afiliación: 07853890.2022.2143554