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Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves.
Panja, Amrita; Roy, Jayita; Mazumder, Anup; Choudhury, Sujata Maiti.
  • Panja A; Midnapore, West Bengal 721102 India Biochemistry, Molecular Endocrinology, and Reproductive Physiology Laboratory, Department of Human Physiology, Vidyasagar University, Paschim Medinipore.
  • Roy J; Nadia, Kalyani, West Bengal 741251 India National Institute of Biomedical Genomics (NIBMG).
  • Mazumder A; Nadia, Kalyani, West Bengal 741251 India National Institute of Biomedical Genomics (NIBMG).
  • Choudhury SM; Midnapore, West Bengal 721102 India Biochemistry, Molecular Endocrinology, and Reproductive Physiology Laboratory, Department of Human Physiology, Vidyasagar University, Paschim Medinipore.
Virusdisease ; : 1-14, 2023 May 10.
Artículo en Inglés | MEDLINE | ID: covidwho-2317977
ABSTRACT
The third SARS-CoV-2 pandemic wave causing Omicron variant has comparatively higher replication rate and transmissibility than the second wave-causing Delta variant. The exact mechanism behind the differential properties of Delta and Omicron in respect to infectivity and virulence is not properly understood yet. This study reports the analysis of different mutations within the receptor binding domain (RBD) of spike glycoprotein and non-structural protein (nsp) of Delta and Omicron strains. We have used computational studies to evaluate the properties of Delta and Omicron variants in this work. Q498R, Q493R and S375F mutations of RBD showed better docking scores for Omicron compared to Delta variant of SARS-CoV-2, whereas nsp3_L1266I with PARP15 (7OUX), nsp3_L1266I with PARP15 (7OUX), and nsp6_G107 with ISG15 (1Z2M) showed significantly higher docking score. The findings of the present study might be helpful to reveal the probable cause of relatively milder form of COVID-19 disease manifested by Omicron in comparison to Delta variant of SARS-CoV-2 virus. Supplementary Information The online version contains supplementary material available at 10.1007/s13337-023-00823-0.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Tópicos: Variantes Idioma: Inglés Revista: Virusdisease Año: 2023 Tipo del documento: Artículo

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Tópicos: Variantes Idioma: Inglés Revista: Virusdisease Año: 2023 Tipo del documento: Artículo