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Efficacy and safety of a fourth dose of the COVID-19 vaccine in kidney transplant recipients: A systematic review and meta-analysis.
Kuniduzi, Yasen; Chen, Bo; Zeng, Jingjing; Sun, Xiaosong; Chen, Tao; Qian, Xiaoyuan; Wang, Jiange; Liang, Fuchao; Abuduxukuer, Rukeya; Yusufu, Maierhaba; Xu, Shaoyong; Zhang, Xuejun.
  • Kuniduzi Y; College of Medicine, Wuhan University of Science and Technology, Wuhan, China; Center for Clinical Evidence-Based and Translational Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China.; Department of Urology, Xiangyang Central Ho
  • Chen B; Center for Clinical Evidence-Based and Translational Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China.
  • Zeng J; Center for Clinical Evidence-Based and Translational Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China.
  • Sun X; Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Chen T; Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Qian X; Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Wang J; Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Liang F; Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Abuduxukuer R; College of Medicine, Wuhan University of Science and Technology, Wuhan, China.
  • Yusufu M; College of Medicine, Wuhan University of Science and Technology, Wuhan, China.
  • Xu S; Center for Clinical Evidence-Based and Translational Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China.; Department of Endocrinology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xian
  • Zhang X; Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China. Electronic address: 3096017279@qq.com.
Transpl Immunol ; 79: 101864, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: covidwho-2324268
ABSTRACT

BACKGROUND:

Kidney transplant recipients (KTRs) who become infected with SARS-CoV-2 are at greater risk of serious illness and death than the general population. To date, the efficacy and safety of the fourth dose of the COVID-19 vaccine in KTRs have not been systematically discussed.

METHODS:

This systematic review and meta-analysis included articles from PubMed, Embase, the Cochrane Library, Web of Science, China National Knowledge Infrastructure, and Wanfang Med Online published before May 15, 2022. Studies evaluating the efficacy and safety of a fourth dose of the COVID-19 vaccine in kidney transplant recipients were selected.

RESULTS:

Nine studies were included in the meta-analysis, with a total of 727 KTRs. The overall pooled seropositivity rate after the fourth COVID-19 vaccine was 60% (95% CI, 49%-71%, I2 = 87.83%, p > 0.01). The pooled proportion of KTRs seronegative after the third dose that transitioned to seropositivity after the fourth dose was 30% (95% CI, 15%-48%, I2 = 94.98%, p < 0.01).

CONCLUSIONS:

The fourth dose of the COVID-19 vaccine was well tolerated in KTRs with no serious adverse effects. Some KTRs showed a reduced response even after receiving the fourth vaccine dose. Overall, the fourth vaccine dose effectively improved seropositivity in KTRs, as recommended by the World Health Organization for the general population.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / COVID-19 Tipo de estudio: Estudio experimental / Estudio pronóstico / Revisiones / Revisión sistemática/Meta análisis Tópicos: Vacunas Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Transpl Immunol Asunto de la revista: Alergia e Inmunología / Trasplante Año: 2023 Tipo del documento: Artículo

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / COVID-19 Tipo de estudio: Estudio experimental / Estudio pronóstico / Revisiones / Revisión sistemática/Meta análisis Tópicos: Vacunas Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Transpl Immunol Asunto de la revista: Alergia e Inmunología / Trasplante Año: 2023 Tipo del documento: Artículo