Threatening drug-drug interaction in a kidney transplant patient with coronavirus disease 2019 (COVID-19).
Transpl Infect Dis
; 22(4): e13286, 2020 Aug.
Artículo
en Inglés
| MEDLINE | ID: covidwho-47858
ABSTRACT
During the novel coronavirus pandemic, organ transplant recipients represent a frail susceptible category due to long-term immunosuppressive therapy. For this reason, clinical manifestations may differ from general population and different treatment approaches may be needed. We present the case of a 36-year-old kidney-transplanted woman affected by Senior-Loken syndrome diagnosed with COVID-19 pneumonia after a contact with her positive mother. Initial symptoms were fatigue, dry cough, and coryza; she never had fever nor oxygen supplementation. Hydroxychloroquine and lopinavir/ritonavir were started, and the antiviral drug was replaced with darunavir/cobicistat after 2 days for diarrhea. Immunosuppressant levels were closely monitored, and we observed very high tacrolimus trough levels despite initial dose reduction. The patient was left with steroid therapy alone. The peculiarity of clinical presentation and the management difficulties represent the flagship of our case report. We stress the need for guidelines in transplant recipients with COVID-19 infection with particular regard to the management of therapy.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Neumonía Viral
/
Trasplante de Riñón
/
Tacrolimus
/
Infecciones por Coronavirus
/
Ritonavir
/
Lopinavir
/
Inhibidores del Citocromo P-450 CYP3A
/
Rechazo de Injerto
/
Inmunosupresores
Tipo de estudio:
Reporte de caso
/
Estudio observacional
/
Estudio pronóstico
Tópicos:
Covid persistente
Idioma:
Inglés
Revista:
Transpl Infect Dis
Asunto de la revista:
Trasplante
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Tid.13286
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