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Baseline characteristics and risk factors for short-term outcomes in 132 COVID-19 patients with diabetes in Wuhan China: A retrospective study.
Li, Yumin; Han, Xiaoyu; Alwalid, Osamah; Cui, Yue; Cao, Yukun; Liu, Jia; Gu, Jin; Wang, Lixia; Fan, Yanqing; Shi, Heshui.
  • Li Y; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.
  • Han X; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.
  • Alwalid O; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.
  • Cui Y; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.
  • Cao Y; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.
  • Liu J; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.
  • Gu J; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.
  • Wang L; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. Electronic address: lisa2003627_1@163.com.
  • Fan Y; Department of Radiology, Wuhan Jinyintan Hospital, No.1 Yintan Road, Dongxihu District, Wuhan 430022, China. Electronic address: 1024932023@qq.com.
  • Shi H; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. Electronic address: heshuishi@hust.edu.cn.
Diabetes Res Clin Pract ; 166: 108299, 2020 Aug.
Artículo en Inglés | MEDLINE | ID: covidwho-912139
ABSTRACT

AIMS:

To investigate the clinical characteristics, laboratory findings and high- resolution CT (HRCT) features and to explore the risk factors for in-hospital death and complications of coronavirus disease 2019 (COVID-19) patients with diabetes.

METHODS:

From Dec 31, 2019, to Apr 5, 2020, a total of 132 laboratory-confirmed COVID-19 patients with diabetes from two hospitals were retrospectively included in our study. Clinical, laboratory and chest CT data were analyzed and compared between the two groups with an admission glucose level of ≤11 mmol/L (group 1) and >11 mmol/L (group 2). Logistic regression analyses were used to identify the risk factors associated with in-hospital death and complications.

RESULTS:

Of 132 patients, 15 died in hospital and 113 were discharged. Patients in group 2 were more likely to require intensive care unit care (21.4% vs. 9.2%), to develop acute respiratory distress syndrome (ARDS) (23.2% vs. 9.2%) and acute cardiac injury (12.5% vs. 1.3%), and had a higher death rate (19.6% vs. 5.3%) than group 1. In the multivariable analysis, patients with admission glucose of >11 mmol/l had an increased risk of death (OR 7.629, 95%CI 1.391-37.984) and in-hospital complications (OR 3.232, 95%CI 1.393-7.498). Admission d-dimer of ≥1.5 µg/mL (OR 6.645, 95%CI 1.212-36.444) and HRCT score of ≥10 (OR 7.792, 95%CI 2.195-28.958) were associated with increased odds of in-hospital death and complications, respectively.

CONCLUSIONS:

In COVID-19 patients with diabetes, poorly-controlled blood glucose (>11 mmol/L) may be associated with poor outcomes. Admission hyperglycemia, elevated d-dimer and high HRCT score are potential risk factors for adverse outcomes and death.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Glucemia / Intolerancia a la Glucosa / Infecciones por Coronavirus / Complicaciones de la Diabetes / Diabetes Mellitus / Betacoronavirus / Hiperglucemia Tipo de estudio: Estudio experimental / Estudio observacional / Estudio pronóstico / Ensayo controlado aleatorizado Tópicos: Covid persistente Límite: Anciano / Femenino / Humanos / Masculino / Middle aged País/Región como asunto: Asia Idioma: Inglés Revista: Diabetes Res Clin Pract Asunto de la revista: Endocrinologia Año: 2020 Tipo del documento: Artículo País de afiliación: J.diabres.2020.108299

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Glucemia / Intolerancia a la Glucosa / Infecciones por Coronavirus / Complicaciones de la Diabetes / Diabetes Mellitus / Betacoronavirus / Hiperglucemia Tipo de estudio: Estudio experimental / Estudio observacional / Estudio pronóstico / Ensayo controlado aleatorizado Tópicos: Covid persistente Límite: Anciano / Femenino / Humanos / Masculino / Middle aged País/Región como asunto: Asia Idioma: Inglés Revista: Diabetes Res Clin Pract Asunto de la revista: Endocrinologia Año: 2020 Tipo del documento: Artículo País de afiliación: J.diabres.2020.108299