Your browser doesn't support javascript.
Obesity and Higher Risk for Severe Complications of Covid-19: What to do when the two pandemics meet.
Valerio, Alessandra; Nisoli, Enzo; Rossi, Andrea P; Pellegrini, Massimo; Todesco, Tiziana; El Ghoch, Marwan.
  • Valerio A; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
  • Nisoli E; Associate Editor - Journal of Population Therapeutics and Clinical Pharmacology, Brisbane, QLD, Australia.
  • Rossi AP; Center for Study and Research on Obesity, Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
  • Pellegrini M; Editorial Board Member - Journal of Population Therapeutics and Clinical Pharmacology, Brisbane, QLD, Australia.
  • Todesco T; Division of Geriatrics, Department of Medicine, Healthy Aging Center, University of Verona, Verona, Italy.
  • El Ghoch M; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
J Popul Ther Clin Pharmacol ; 27(S Pt 1): e31-e36, 2020 Jun 29.
Artículo en Inglés | MEDLINE | ID: covidwho-639793
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic has spread around the globe, infecting more than ten million individuals, with more than 500,000 dead; about one half of the infected people have recovered. Despite this fact, a subgroup of individuals affected by COVID-19 is at greater risk of developing worse outcomes and experience a high rate of mortality. Data on the association between obesity and COVID-19 are growing; the available studies, have reported a high prevalence of overweight and obesity in patients experiencing a severe COVID-19 course, with serious complications requiring hospitalization and admission to intensive care units. This paper attempts to highlight potential mechanisms behind the greater vulnerability to COVID-19 of individuals with obesity. The presence of uncontrolled chronic obesity-related comorbidities, particularly pulmonary diseases, can present a primary fertile soil for respiratory tract infection. Combined with immune system impairments, such as alteration in the T-cell proliferation and macrophage differentiation, and the high pro-inflammatory cytokine production by the adipose organ, this may worsen the general condition toward a systemic diffusion of infection. Prevention remains the first line of intervention in these patients that can be achieved by adhering to social distancing and adopting hygiene precautions, combined with a healthy lifestyle. Patients with obesity require preferential access dedicated to primary care services to ensure they are regularly taking their medications for the treatment of any concurrent chronic diseases. Finally, their physicians must promptly manage any medical signs or symptoms in the case of suspected severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) infection to prevent the risk of severe outcomes.
Asunto(s)
Palabras clave

Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infecciones por Coronavirus / Obesidad Tipo de estudio: Estudio observacional / Estudio pronóstico Tópicos: Covid persistente Límite: Humanos Idioma: Inglés Revista: J Popul Ther Clin Pharmacol Asunto de la revista: Farmacología / Terapia por drogas Año: 2020 Tipo del documento: Artículo País de afiliación: Jptcp.v27iSP1.708

Similares

MEDLINE

...
LILACS

LIS


Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infecciones por Coronavirus / Obesidad Tipo de estudio: Estudio observacional / Estudio pronóstico Tópicos: Covid persistente Límite: Humanos Idioma: Inglés Revista: J Popul Ther Clin Pharmacol Asunto de la revista: Farmacología / Terapia por drogas Año: 2020 Tipo del documento: Artículo País de afiliación: Jptcp.v27iSP1.708