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Late histological findings in symptomatic COVID-19 patients: A case report.
Aiolfi, Alberto; Bruni, Barbara; Biraghi, Tullio; Montisci, Andrea; Miceli, Antonio; Baronio, Barbara; Khor, Desmond; Cirri, Silvia; Donatelli, Francesco; Clemente, Claudio; Bona, Davide.
  • Aiolfi A; Department of Biomedical Science for Health, Division of General Surgery, Istitituto Clinico Sant'Ambrogio, University of Milan.
  • Bruni B; Department of Pathology, I.R.C.C.S. Policlinico San Donato, Milano.
  • Biraghi T; Department of Biomedical Science for Health, Division of General Surgery, Istitituto Clinico Sant'Ambrogio, University of Milan.
  • Montisci A; Department of Anaesthesia and Intensive Care, Cardiothoracic Center, Istituto Clinico Sant'Ambrogio, University of Milan.
  • Miceli A; Department of Anaesthesia and Intensive Care, Cardiothoracic Center, Istituto Clinico Sant'Ambrogio, University of Milan.
  • Baronio B; Department of Anaesthesia and Intensive Care, Cardiothoracic Center, Istituto Clinico Sant'Ambrogio, University of Milan.
  • Khor D; Department of Biomedical Science for Health, Division of General Surgery, Istitituto Clinico Sant'Ambrogio, University of Milan.
  • Cirri S; Department of Anaesthesia and Intensive Care, Cardiothoracic Center, Istituto Clinico Sant'Ambrogio, University of Milan.
  • Donatelli F; Chair of Cardiac Surgery, Department of Cardiothoracic Center, Istituto Clinico Sant'Ambrogio; University of Milan, Milano, Italy.
  • Clemente C; Department of Pathology, I.R.C.C.S. Policlinico San Donato, Milano.
  • Bona D; Department of Biomedical Science for Health, Division of General Surgery, Istitituto Clinico Sant'Ambrogio, University of Milan.
Medicine (Baltimore) ; 99(28): e21046, 2020 Jul 10.
Artículo en Inglés | MEDLINE | ID: covidwho-646088
ABSTRACT
RATIONALE Although there have been several studies describing clinical and radiographic features about the novel coronavirus (COVID-19) infection, there is a lack of pathologic data conducted on biopsies or autopsies. PATIENT CONCERNS A 56-year-old and a 70-year-old men with fever, cough, and respiratory fatigue were admitted to the intensive care unit and intubated for respiratory distress. DIAGNOSIS The nasopharyngeal swab was positive for COVID-19 and the chest Computed Tomography (CT) scan showed the presence of peripheral and bilateral ground-glass opacities.

INTERVENTIONS:

Both patients developed pneumothoraces after intubation and was managed with chest tube. Due to persistent air leak, thoracoscopies with blebs resection and pleurectomies were performed on 23rd and 16th days from symptoms onset.

OUTCOMES:

The procedures were successful with no evidence of postoperative air-leak, with respiratory improvement. Pathological specimens were analyzed with evidence of diffuse alveolar septum disruption, interstitium thickness, and infiltration of inflammatory cells with diffuse endothelial dysfunction and hemorrhagic thrombosis. LESSONS Despite well-known pulmonary damages induced by the COVID-19, the late-phase histological changes include diffused peripheral vessels endothelial hyperplasia, in toto muscular wall thickening, and intravascular hemorrhagic thrombosis.
Asunto(s)

Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Pleura / Neumonía Viral / Trombosis / Endotelio Vascular / Infecciones por Coronavirus / Pandemias / Pulmón Tipo de estudio: Reporte de caso / Estudios diagnósticos / Estudio pronóstico Tópicos: Covid persistente Idioma: Inglés Revista: Medicine (Baltimore) Año: 2020 Tipo del documento: Artículo

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Pleura / Neumonía Viral / Trombosis / Endotelio Vascular / Infecciones por Coronavirus / Pandemias / Pulmón Tipo de estudio: Reporte de caso / Estudios diagnósticos / Estudio pronóstico Tópicos: Covid persistente Idioma: Inglés Revista: Medicine (Baltimore) Año: 2020 Tipo del documento: Artículo