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Hydroxychloroquine and Chloroquine in COVID-19: A Survey of Prescription Patterns Among Rheumatologists.
Mehta, Bella; Moezinia, Carine J; Jannat-Khah, Deanna; Gibofsky, Allan; Tornberg, Haley; Pearce-Fisher, Diyu; Goodman, Susan M; Salmon, Jane E; Ibrahim, Said.
  • Moezinia CJ; From the Hospital for Special Surgery.
  • Gibofsky A; From the Hospital for Special Surgery.
  • Tornberg H; From the Hospital for Special Surgery.
  • Pearce-Fisher D; From the Hospital for Special Surgery.
  • Salmon JE; From the Hospital for Special Surgery.
J Clin Rheumatol ; 26(6): 224-228, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: covidwho-660018
ABSTRACT

OBJECTIVE:

With hydroxychloroquine (HCQ) and chloroquine (CQ) emerging as potential therapies for coronavirus disease 2019 (COVID-19), shortages have been reported. We aimed to understand how rheumatologists, one of the most common prescribers of HCQ/CQ, prescribed these medications to manage COVID-19 and to understand if their patients are affected by shortages.

METHODS:

Between April 8 and April 27, 2020, an online survey was distributed to a convenience sample of rheumatologists who practice medicine in a diverse range of settings globally, resulting in 506 responses. Adjusted Poisson regression models were calculated.

RESULTS:

Only 6% of respondents prescribed HCQ/CQ for COVID-19 prophylaxis, and only 12% for outpatient treatment of COVID-19. Compared to the United States, the likelihood of prescribing HCQ/CQ for prophylaxis was higher in India (adjusted risk ratio [aRR], 6.7; 95% confidence interval [CI], 2.7-16.8; p < 0.001). Further, compared to the United States and those with 1 to 5 years of experience, rheumatologists in Europe (aRR, 2.9; 95% CI, 1.6-5.3; p < 0.001) and those with 10+ years of experience (11-20 years aRR, 2.5; 95% CI, 1.2-5.3; p = 0.015; 21+ years aRR = 3.3; 95% CI, 1.4-7.4; p = 0.004) had a higher likelihood of prescribing HCQ/CQ for outpatient treatment. Of note, 71% of all rheumatologists reported that their patients were directly affected by HCQ/CQ shortages.

CONCLUSION:

The results suggest that only a small percentage of rheumatologists are prescribing HCQ/CQ for prophylaxis or outpatient treatment of COVID-19. Medication shortages experienced by large numbers of autoimmune disease patients are concerning and should play a role in decisions, especially given poor efficacy data for HCQ/CQ in COVID-19.
Asunto(s)

Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Reumatología / Pautas de la Práctica en Medicina / Infecciones por Coronavirus / Pandemias / Betacoronavirus / Hidroxicloroquina Tipo de estudio: Estudio observacional / Estudio pronóstico / Ensayo controlado aleatorizado Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: J Clin Rheumatol Asunto de la revista: Fisiología / Ortopedia / Reumatología Año: 2020 Tipo del documento: Artículo

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Reumatología / Pautas de la Práctica en Medicina / Infecciones por Coronavirus / Pandemias / Betacoronavirus / Hidroxicloroquina Tipo de estudio: Estudio observacional / Estudio pronóstico / Ensayo controlado aleatorizado Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: J Clin Rheumatol Asunto de la revista: Fisiología / Ortopedia / Reumatología Año: 2020 Tipo del documento: Artículo