Analysis of thin-section CT in patients with coronavirus disease (COVID-19) after hospital discharge.
J Xray Sci Technol
; 28(3): 383-389, 2020.
Artículo
en Inglés
| MEDLINE | ID: covidwho-661071
ABSTRACT
PURPOSE:
To analyze clinical and thin-section computed tomographic (CT) data from the patients with coronavirus disease (COVID-19) to predict the development of pulmonary fibrosis after hospital discharge. MATERIALS ANDMETHODS:
Fifty-nine patients (31 males and 28 females ranging from 25 to 70 years old) with confirmed COVID-19 infection performed follow-up thin-section thorax CT. After 31.5±7.9 days (range, 24 to 39 days) of hospital admission, the results of CT were analyzed for parenchymal abnormality (ground-glass opacification, interstitial thickening, and consolidation) and evidence of fibrosis (parenchymal band, traction bronchiectasis, and irregular interfaces). Patients were analyzed based on the evidence of fibrosis and divided into two groups namely, groups A and B (with and without CT evidence of fibrosis), respectively. Patient demographics, length of stay (LOS), rate of intensive care unit (ICU) admission, peak C-reactive protein level, and CT score were compared between the two groups.RESULTS:
Among the 59 patients, 89.8% (53/59) had a typical transition from early phase to advanced phase and advanced phase to dissipating phase. Also, 39% (23/59) patients developed fibrosis (group A), whereas 61% (36/59) patients did not show definite fibrosis (group B). Patients in group A were older (mean age, 45.4±16.9 vs. 33.8±10.2 years) (Pâ=â0.001), with longer LOS (19.1±5.2 vs. 15.0±2.5 days) (Pâ=â0.001), higher rate of ICU admission (21.7% (5/23) vs. 5.6% (2/36)) (Pâ=â0.061), higher peak C-reactive protein level (30.7±26.4 vs. 18.1±17.9âmg/L) (Pâ=â0.041), and higher maximal CT score (5.2±4.3 vs. 4.0±2.2) (Pâ=â0.06) than those in group B.CONCLUSIONS:
Pulmonary fibrosis may develop early in patients with COVID-19 after hospital discharge. Older patients with severe illness during treatment were more prone to develop fibrosis according to thin-section CT results.Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Alta del Paciente
/
Neumonía Viral
/
Fibrosis Pulmonar
/
Tomografía Computarizada por Rayos X
/
Infecciones por Coronavirus
/
Betacoronavirus
/
Pulmón
Tipo de estudio:
Estudio de cohorte
/
Estudio experimental
/
Estudio observacional
/
Estudio pronóstico
/
Ensayo controlado aleatorizado
Tópicos:
Covid persistente
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Middle aged
Idioma:
Inglés
Revista:
J Xray Sci Technol
Asunto de la revista:
Radiología
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
XST-200685
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