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Pan­cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS­CoV­2 infection leading to COVID-19.
Katopodis, Periklis; Anikin, Vladimir; Randeva, Harpal S; Spandidos, Demetrios A; Chatha, Kamaljit; Kyrou, Ioannis; Karteris, Emmanouil.
  • Katopodis P; Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.
  • Anikin V; Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.
  • Randeva HS; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK.
  • Spandidos DA; Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
  • Chatha K; Department of Biochemistry and Immunology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK.
  • Kyrou I; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK.
  • Karteris E; Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.
Int J Oncol ; 57(2): 533-539, 2020 08.
Artículo en Inglés | MEDLINE | ID: covidwho-667782
ABSTRACT
Severe acute respiratory syndrome (SARS) coronavirus­2 (SARS­CoV2) is the cause of a new disease (COVID­19) which has evolved into a pandemic during the first half of 2020. Older age, male sex and certain underlying diseases, including cancer, appear to significantly increase the risk for severe COVID­19. SARS­CoV­2 infection of host cells is facilitated by the angiotensin­converting enzyme 2 (ACE­2), and by transmembrane protease serine 2 (TMPRSS2) and other host cell proteases such as cathepsin L (CTSL). With the exception of ACE­2, a systematic analysis of these two other SARS­CoV2 infection mediators in malignancies is lacking. Here, we analysed genetic alteration, RNA expression, and DNA methylation of TMPRSS2 and CTSL across a wide spectrum of tumors and controls. TMPRSS2 was overexpressed in cervical squamous cell carcinoma and endocervical adenocarcinoma, colon adenocarcinoma, prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), uterine corpus endometrial carcinoma and uterine carcinosarcoma, with PRAD and READ exhibiting the highest expression of all cancers. CTSL was upregulated in lymphoid neoplasm diffuse large B­cell lymphoma, oesophageal carcinoma, glioblastoma multiforme, head and neck squamous cell carcinoma, lower grade glioma, pancreatic adenocarcinoma, skin cutaneous melanoma, stomach adenocarcinoma, and thymoma. Hypo­methylation of both genes was evident in most cases where they have been highly upregulated. We have expanded on our observations by including data relating to mutations and copy number alterations at pan­cancer level. The novel hypotheses that are stemming out of these data need to be further investigated and validated in large clinical studies.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infecciones Oportunistas / Serina Endopeptidasas / Biomarcadores de Tumor / Infecciones por Coronavirus / Internalización del Virus / Catepsina L / Betacoronavirus / Neoplasias Tipo de estudio: Estudio observacional / Estudio pronóstico / Revisión sistemática/Meta análisis Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Int J Oncol Asunto de la revista: Neoplasmas Año: 2020 Tipo del documento: Artículo País de afiliación: Ijo.2020.5071

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infecciones Oportunistas / Serina Endopeptidasas / Biomarcadores de Tumor / Infecciones por Coronavirus / Internalización del Virus / Catepsina L / Betacoronavirus / Neoplasias Tipo de estudio: Estudio observacional / Estudio pronóstico / Revisión sistemática/Meta análisis Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Int J Oncol Asunto de la revista: Neoplasmas Año: 2020 Tipo del documento: Artículo País de afiliación: Ijo.2020.5071