Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2-Infected Macaques.
J Infect Dis
; 222(10): 1596-1600, 2020 10 13.
Artículo
en Inglés
| MEDLINE | ID: covidwho-693639
ABSTRACT
Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Enfermedades Pulmonares Intersticiales
/
Infecciones por Coronavirus
/
Modelos Animales de Enfermedad
/
Betacoronavirus
/
Linfopenia
/
Enfermedades de los Monos
Tópicos:
Covid persistente
Límite:
Animales
Idioma:
Inglés
Revista:
J Infect Dis
Año:
2020
Tipo del documento:
Artículo
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