[Pharmacological treatment in uncertainty times: Hydroxychloroquine/chloroquine use in the COVID-19 treatment]. / Tratamiento farmacológico en tiempos de incertidumbre: uso de la hidroxicloroquina/cloroquina en el tratamiento de COVID-19.
Semergen
; 46 Suppl 1: 20-27, 2020 Aug.
Artículo
en Español
| MEDLINE | ID: covidwho-1195448
ABSTRACT
BACKGROUND AND OBJECTIVES:
In this moments, of extreme gravity in which we find ourselves, and in the uncertainty face about the most effective treatment against COVID-19 disease and with the aim of find the evidence that support the chloroquine/hydroxychloroquine use recommendation to treat COVID-19 disease, a systematic review of published studies and RCT studies publishes until April 28, 2020 was carried out. MATERIAL ANDMETHODS:
A systematic search was carried out in PubMed with the keywords COVID-19 and their synonyms and hydroxychloroquine/chloroquine. The data selection and extraction was elaborated by two researchers, independently. The results were discussed with a Primary Care physicians clinical group and the results were synthesized using GRADE methodology.RESULTS:
A good quality systematic review was found that includes articles with a high risk of bias. And 8 EC launched that will produce results beyond May 2020.CONCLUSIONS:
Although the conclusions of the systematic review generate a low confidence in the results, and the clinical variables that show benefit are intermediate variables, the side effects are acceptable and could be minimized with the use of QT lengthening risk tools, so it is could make a weak recommendation in favor of the use of chloroquine/hydroxychloroquine in patients with mild-moderate stage COVID-19.Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Cloroquina
Tipo de estudio:
Estudio pronóstico
/
Revisiones
/
Revisión sistemática/Meta análisis
Límite:
Humanos
Idioma:
Español
Revista:
Semergen
Año:
2020
Tipo del documento:
Artículo
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