Coronavirus disease 2019 (COVID-19) in autoimmune and inflammatory conditions: clinical characteristics of poor outcomes.
Rheumatol Int
; 40(10): 1593-1598, 2020 Oct.
Artículo
en Inglés
| MEDLINE | ID: covidwho-713879
ABSTRACT
OBJECTIVE:
To describe clinical characteristics of patients with rheumatic and musculoskeletal diseases (RMDs) and immunosuppressive therapies with Coronavirus disease 2019 (COVID-19) at an academic rheumatology center in Madrid and to identify baseline variables associated with a severe infection requiring hospitalization.METHODS:
We identified SARS-CoV-2 positive cases by polymerase chain reaction performed at our center within an updated RMDs database in our clinic. Additional RMDs patients were identified when they contacted the clinic because of a positive infection. Data extraction included diagnosis, demographics, immunosuppressive treatment, comorbidities, and laboratory tests. Comparisons between patients with or without hospitalization were performed. Multivariate logistic regression was used to analyze associations between baseline variables and need for hospitalization.RESULTS:
A total of 62 patients with COVID-19 and underlying RMDs were identified by April 24, 2020. Median age was 60.9 years, and 42% men. Forty-two patients required hospitalization; these were more frequently men, older and with comorbidities. There were no statistically significant between-group differences for rheumatologic diagnosis and for baseline use of immunosuppressive therapy except for glucocorticoids that were more frequent in hospitalized patients. Total deaths were 10 (16%) patients. In multivariate analysis, male sex (odds ratio [OR], 8.63; p = 0.018), previous lung disease (OR, 27.47; p = 0.042), and glucocorticoids use (> 5 mg/day) (OR, 9.95; p = 0.019) were significantly associated to hospitalization.CONCLUSION:
Neither specific RMD diagnoses or exposures to DMARDs were associated with increased odds of hospitalization. Being male, previous lung disease and exposure to glucocorticoids were associated with higher odds of hospitalization in RMDs patients.Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Artritis Reumatoide
/
Artritis Psoriásica
/
Infecciones por Coronavirus
/
Glucocorticoides
/
Hospitalización
/
Inmunosupresores
/
Lupus Eritematoso Sistémico
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Revisiones
Tópicos:
Covid persistente
País/Región como asunto:
Europa
Idioma:
Inglés
Revista:
Rheumatol Int
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
S00296-020-04676-4
Similares
MEDLINE
...
LILACS
LIS