Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?
Mol Med
; 26(1): 80, 2020 08 17.
Artículo
en Inglés
| MEDLINE | ID: covidwho-717479
ABSTRACT
Infection of lung cells by the corona virus results in a loss of the balance between, on the one hand, angiotensin II-mediated stimulation of the angiotensin II type 1 receptor and, on the other hand, stimulation of the angiotensin II type 2 receptor and/or the Mas receptor. The unbalanced enhanced stimulation of the angiotensin II type 1 receptor causes inflammation, edema and contributes to the pathogenesis of severe acute respiratory distress syndrome. Here we hypothesize that stable, receptor-specific agonists of the angiotensin II type 2 receptor and of the Mas receptor are molecular medicines to treat COVID-19 patients. These agonists have therapeutic potential in the acute disease but in addition may reduce COVID-19-associated long-term pulmonary dysfunction and overall end-organ damage of this disease.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Sistema Renina-Angiotensina
/
Peptidil-Dipeptidasa A
/
Receptor de Angiotensina Tipo 2
Tipo de estudio:
Estudio pronóstico
/
Ensayo controlado aleatorizado
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Mol Med
Asunto de la revista:
Biologia Molecular
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
S10020-020-00211-0
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