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Severe Clostridium difficile colitis as potential late complication associated with COVID-19.
Páramo-Zunzunegui, J; Ortega-Fernández, I; Calvo-Espino, P; Diego-Hernández, C; Ariza-Ibarra, I; Otazu-Canals, L; Danés-Grases, J E; Menchero-Sánchez, A.
  • Páramo-Zunzunegui J; Department of General and Digestive Surgery, University Hospital of Móstoles, Madrid, Spain.
  • Ortega-Fernández I; Department of General and Digestive Surgery, University Hospital of Móstoles, Madrid, Spain.
  • Calvo-Espino P; Department of General and Digestive Surgery, University Hospital of Móstoles, Madrid, Spain.
  • Diego-Hernández C; Department of Histopathology, University Hospital of Móstoles, Madrid, Spain.
  • Ariza-Ibarra I; Department of General and Digestive Surgery, University Hospital of Móstoles, Madrid, Spain.
  • Otazu-Canals L; Department of General and Digestive Surgery, University Hospital of Móstoles, Madrid, Spain.
  • Danés-Grases JE; Department of General and Digestive Surgery, University Hospital of Móstoles, Madrid, Spain.
  • Menchero-Sánchez A; Department of General and Digestive Surgery, University Hospital of Móstoles, Madrid, Spain.
Ann R Coll Surg Engl ; 102(7): e176-e179, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: covidwho-721361
ABSTRACT
Spain has been one of the most affected countries by the COVID-19 outbreak. After the high impact of the pandemic, a wide clinical spectrum of late complications associated with COVID-19 are being observed. We report a case of a severe Clostridium difficile colitis in a post-treatment and recovered COVID-19 patient. A 64-year-woman with a one-month hospital admission for severe bilateral pneumonia associated with COVID-19 and 10 days after discharge presented with diarrhoea and abdominal pain. Severe C. difficile-associated colitis is diagnosed according to clinical features and CT findings. An urgent pancolectomy was performed due to her bad response to conservative treatment. Later evolution slowly improved to recovery. C. difficile-associated colitis is one of the most common hospital-acquired infections. Significant patient-related risk factors for C. difficile infection are antibiotic exposure, older age, and hospitalisation. Initial therapeutic recommendations in our country included administration broad-spectrum antibiotics to all patients with bilateral pneumonia associated with SARS-CoV-2. These antibiotics are strongly associated with C. difficile infection. Our patient developed a serious complication of C. difficile due to the use of broad-spectrum antibiotics. The appearance of late digestive symptoms in patients diagnosed and treated for COVID-19 should alert clinicians to the possibility of C. difficile infection. The updated criteria for severe colitis and severe C. difficile infection should be considered to ensure an early effective treatment for the complication.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infección Hospitalaria / Clostridioides difficile / Colitis / Infecciones por Coronavirus / Betacoronavirus / Antibacterianos Tipo de estudio: Reporte de caso / Estudio de cohorte / Estudios diagnósticos / Estudio observacional / Estudio pronóstico / Ensayo controlado aleatorizado Tópicos: Covid persistente Límite: Femenino / Humanos / Middle aged Idioma: Inglés Revista: Ann R Coll Surg Engl Año: 2020 Tipo del documento: Artículo País de afiliación: Rcsann.2020.0166

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infección Hospitalaria / Clostridioides difficile / Colitis / Infecciones por Coronavirus / Betacoronavirus / Antibacterianos Tipo de estudio: Reporte de caso / Estudio de cohorte / Estudios diagnósticos / Estudio observacional / Estudio pronóstico / Ensayo controlado aleatorizado Tópicos: Covid persistente Límite: Femenino / Humanos / Middle aged Idioma: Inglés Revista: Ann R Coll Surg Engl Año: 2020 Tipo del documento: Artículo País de afiliación: Rcsann.2020.0166