Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms.
Mol Neurobiol
; 57(12): 5263-5275, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: covidwho-738570
ABSTRACT
Similar to its predecessors, coronavirus disease 2019 (COVID-19) exhibits neurotrophic properties, which lead to progression of neurologic sequelae. Besides direct viral invasion to the central nervous system (CNS), indirect CNS involvement through viral-mediated immune response is plausible. Aberrant immune pathways such as extreme release of cytokines (cytokine storm), autoimmunity mediated by cross-reactivity between CNS components and viral particles, and microglial activation propagate CNS damage in these patients. Here, we review the currently available evidence to discuss the plausible immunologic pathways that may contribute to the development of COVID-19 neurological complications, namely Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis, Guillain-Barre syndrome, seizure, and brainstem involvement.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Infecciones por Coronavirus
/
Pandemias
/
Betacoronavirus
/
Enfermedades del Sistema Nervioso
Tipo de estudio:
Estudio observacional
/
Ensayo controlado aleatorizado
Tópicos:
Covid persistente
Idioma:
Inglés
Revista:
Mol Neurobiol
Asunto de la revista:
Biologia Molecular
/
Neurología
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
S12035-020-02094-y
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