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Clinical Study of Hyperglycemia and SARS-CoV-2 Infection in Intensive Care Unit Patients.
Ilias, Ioannis; Jahaj, Edison; Kokkoris, Stylianos; Zervakis, Dimitrios; Temperikidis, Prodromos; Magira, Eleni; Pratikaki, Maria; Vassiliou, Alice G; Routsi, Christina; Kotanidou, Anastasia; Dimopoulou, Ioanna.
  • Ilias I; Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou Hospital, Athens, Greece iiliasmd@yahoo.com.
  • Jahaj E; 1 Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.
  • Kokkoris S; 1 Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.
  • Zervakis D; 1 Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.
  • Temperikidis P; 1 Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.
  • Magira E; 1 Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.
  • Pratikaki M; 1 Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.
  • Vassiliou AG; 1 Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.
  • Routsi C; 1 Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.
  • Kotanidou A; 1 Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.
  • Dimopoulou I; 1 Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.
In Vivo ; 34(5): 3029-3032, 2020.
Artículo en Inglés | MEDLINE | ID: covidwho-740633
ABSTRACT
BACKGROUND/

AIM:

Reports indicate that coronaviridae may inhibit insulin secretion. In this report we aimed to describe the course of glycemia in critically ill patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. PATIENTS AND

METHODS:

We studied 36 SARS-CoV-2 patients (with no history of diabetes) in one intensive care unit (ICU). All the patients were admitted for hypoxemic respiratory failure; all but four required mechanical ventilation. The mean (±SD) age of the patients was 64.7 (9.7) years; 27 were men; the mean (±SD) duration of ICU stay was 12.9 (8.3 days).

RESULTS:

Twenty of 36 patients presented with hyperglycemia; brief intravenous infusions of short-acting insulin were administered in six patients. As of May 29 2020, 11 patients had died (seven with hyperglycemia). In 17 patients the Hyperglycemia Index [HGI; defined as the area under the curve of (hyper)glycemia level*time (h) divided by the total time in the ICU] was <16.21 mg/dl (0.90 mmol/l), whereas in three patients the HGI was ≥16.21 mg/dl (0.90 mol/l) and <32.25 mg/dl (1.79 mmol/l).

CONCLUSION:

In our series of ICU patients with SARS-CoV-2 infection, and no history of diabetes, a substantial number of patients had hyperglycemia, to a higher degree than would be expected by the stress of critical illness, lending credence to reports that speculated a tentative association between SARS-CoV-2 and hyperglycemia. This finding is important, since hyperglycemia can lead to further infectious complications.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infecciones por Coronavirus / Diabetes Mellitus / Hiperglucemia / Insulina Tipo de estudio: Estudio pronóstico Tópicos: Covid persistente Límite: Femenino / Humanos / Masculino / Middle aged Idioma: Inglés Revista: In Vivo Asunto de la revista: Neoplasmas Año: 2020 Tipo del documento: Artículo País de afiliación: Invivo.12136

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infecciones por Coronavirus / Diabetes Mellitus / Hiperglucemia / Insulina Tipo de estudio: Estudio pronóstico Tópicos: Covid persistente Límite: Femenino / Humanos / Masculino / Middle aged Idioma: Inglés Revista: In Vivo Asunto de la revista: Neoplasmas Año: 2020 Tipo del documento: Artículo País de afiliación: Invivo.12136