Repeated ketamine injections in synergy with antidepressants for treating refractory depression: A case showing 6-month improvement.
J Clin Pharm Ther
; 45(1): 199-203, 2020 Feb.
Artículo
en Inglés
| MEDLINE | ID: covidwho-838508
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
Some patients with refractory depression who fail to respond to rapid injection of standard-dose ketamine are injected with high doses, but the safety and efficacy of this practice are unclear. CASE DESCRIPTION A 57-year-old woman with refractory depression whose symptoms did not improve after 20-seconds intravenous injection of 0.5 mg/kg ketamine went into remission following eight, 1-minute intravenous injections of 1 mg/kg ketamine delivered over a 4-week period. By 6-month follow-up, no significant adverse events had occurred and cognitive function had improved. WHAT IS NEW ANDCONCLUSION:
High-dose intravenous injections of ketamine may stably improve depressive symptoms and cognitive function in patients with refractory depression who do not respond to rapid intravenous injection of standard-dose ketamine. The high-dose treatment appears to be associated with only mild side effects.Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Trastorno Depresivo Mayor
/
Trastorno Depresivo Resistente al Tratamiento
/
Ketamina
/
Antidepresivos
Tipo de estudio:
Reporte de caso
/
Estudio de cohorte
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Middle aged
Idioma:
Inglés
Revista:
J Clin Pharm Ther
Asunto de la revista:
Farmacia
/
Terapeutica
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Jcpt.13041
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