Your browser doesn't support javascript.
Neutrophil extracellular traps in COVID-19.
Zuo, Yu; Yalavarthi, Srilakshmi; Shi, Hui; Gockman, Kelsey; Zuo, Melanie; Madison, Jacqueline A; Blair, Christopher; Weber, Andrew; Barnes, Betsy J; Egeblad, Mikala; Woods, Robert J; Kanthi, Yogendra; Knight, Jason S.
  • Zuo Y; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Yalavarthi S; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Shi H; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Gockman K; Division of Rheumatology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Zuo M; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Madison JA; Division of Geriatric and Palliative Medicine and.
  • Blair C; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Weber A; Division of Infectious Disease, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Barnes BJ; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Northwell Health, New York, New York, USA.
  • Egeblad M; Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, The Feinstein Institutes for Medical Research, Manhasset, New York, USA.
  • Woods RJ; Departments of Molecular Medicine and Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
  • Kanthi Y; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
  • Knight JS; Division of Infectious Disease, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
JCI Insight ; 5(11)2020 06 04.
Artículo en Inglés | MEDLINE | ID: covidwho-980226
ABSTRACT
In severe cases of coronavirus disease 2019 (COVID-19), viral pneumonia progresses to respiratory failure. Neutrophil extracellular traps (NETs) are extracellular webs of chromatin, microbicidal proteins, and oxidant enzymes that are released by neutrophils to contain infections. However, when not properly regulated, NETs have the potential to propagate inflammation and microvascular thrombosis - including in the lungs of patients with acute respiratory distress syndrome. We now report that sera from patients with COVID-19 have elevated levels of cell-free DNA, myeloperoxidase-DNA (MPO-DNA), and citrullinated histone H3 (Cit-H3); the latter 2 are specific markers of NETs. Highlighting the potential clinical relevance of these findings, cell-free DNA strongly correlated with acute-phase reactants, including C-reactive protein, D-dimer, and lactate dehydrogenase, as well as absolute neutrophil count. MPO-DNA associated with both cell-free DNA and absolute neutrophil count, while Cit-H3 correlated with platelet levels. Importantly, both cell-free DNA and MPO-DNA were higher in hospitalized patients receiving mechanical ventilation as compared with hospitalized patients breathing room air. Finally, sera from individuals with COVID-19 triggered NET release from control neutrophils in vitro. Future studies should investigate the predictive power of circulating NETs in longitudinal cohorts and determine the extent to which NETs may be novel therapeutic targets in severe COVID-19.
Asunto(s)
Palabras clave

Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Histonas / Infecciones por Coronavirus / Peroxidasa / Trampas Extracelulares / Ácidos Nucleicos Libres de Células / Neutrófilos Tipo de estudio: Estudio de cohorte / Estudio observacional / Estudio pronóstico Límite: Adulto / Anciano / Femenino / Humanos / Masculino / Middle aged Idioma: Inglés Año: 2020 Tipo del documento: Artículo País de afiliación: Jci.insight.138999

Similares

MEDLINE

...
LILACS

LIS


Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Histonas / Infecciones por Coronavirus / Peroxidasa / Trampas Extracelulares / Ácidos Nucleicos Libres de Células / Neutrófilos Tipo de estudio: Estudio de cohorte / Estudio observacional / Estudio pronóstico Límite: Adulto / Anciano / Femenino / Humanos / Masculino / Middle aged Idioma: Inglés Año: 2020 Tipo del documento: Artículo País de afiliación: Jci.insight.138999