Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2.
Front Med (Lausanne)
; 8: 585358, 2021.
Article
Dans Anglais
| MEDLINE | ID: covidwho-1116697
ABSTRACT
The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
langue:
Anglais
Revue:
Front Med (Lausanne)
Année:
2021
Type de document:
Article
Pays d'affiliation:
Fmed.2021.585358
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