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Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2.
Wang, Daxi; Wang, Yanqun; Sun, Wanying; Zhang, Lu; Ji, Jingkai; Zhang, Zhaoyong; Cheng, Xinyi; Li, Yimin; Xiao, Fei; Zhu, Airu; Zhong, Bei; Ruan, Shicong; Li, Jiandong; Ren, Peidi; Ou, Zhihua; Xiao, Minfeng; Li, Min; Deng, Ziqing; Zhong, Huanzi; Li, Fuqiang; Wang, Wen-Jing; Zhang, Yongwei; Chen, Weijun; Zhu, Shida; Xu, Xun; Jin, Xin; Zhao, Jingxian; Zhong, Nanshan; Zhang, Wenwei; Zhao, Jincun; Li, Junhua; Xu, Yonghao.
  • Wang D; BGI-Shenzhen, Shenzhen, China.
  • Wang Y; Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen, China.
  • Sun W; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Zhang L; BGI-Shenzhen, Shenzhen, China.
  • Ji J; Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen, China.
  • Zhang Z; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
  • Cheng X; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Li Y; Institute of Infectious Disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University, Guangzhou, China.
  • Xiao F; BGI-Shenzhen, Shenzhen, China.
  • Zhu A; Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen, China.
  • Zhong B; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Ruan S; BGI-Shenzhen, Shenzhen, China.
  • Li J; Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen, China.
  • Ren P; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.
  • Ou Z; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Xiao M; Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Infectious Diseases, Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
  • Li M; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Deng Z; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China.
  • Zhong H; Yangjiang People's Hospital, Yangjiang, China.
  • Li F; BGI-Shenzhen, Shenzhen, China.
  • Wang WJ; Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen, China.
  • Zhang Y; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
  • Chen W; BGI-Shenzhen, Shenzhen, China.
  • Zhu S; Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen, China.
  • Xu X; BGI-Shenzhen, Shenzhen, China.
  • Jin X; Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen, China.
  • Zhao J; BGI-Shenzhen, Shenzhen, China.
  • Zhong N; Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen, China.
  • Zhang W; BGI-Shenzhen, Shenzhen, China.
  • Zhao J; Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen, China.
  • Li J; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
  • Xu Y; BGI-Shenzhen, Shenzhen, China.
Front Med (Lausanne) ; 8: 585358, 2021.
Article Dans Anglais | MEDLINE | ID: covidwho-1116697
ABSTRACT
The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.
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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE langue: Anglais Revue: Front Med (Lausanne) Année: 2021 Type de document: Article Pays d'affiliation: Fmed.2021.585358

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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE langue: Anglais Revue: Front Med (Lausanne) Année: 2021 Type de document: Article Pays d'affiliation: Fmed.2021.585358