Serum levels of the IgA isotype switch factor TGF-ß1 are elevated in patients with COVID-19.

Wang, Er-Yi; Chen, Hao; Sun, Bao-Qing; Wang, Hui; Qu, Hui-Qi; Liu, Yichuan; Sun, Xi-Zhuo; Qu, Jingchun; Fang, Zhang-Fu; Tian, Lifeng; Zeng, Yi-Feng; Huang, Shau-Ku; Hakonarson, Hakon; Liu, Zhi-Gang

Wang, Er-Yi; Chen, Hao; Sun, Bao-Qing; Wang, Hui; Qu, Hui-Qi; Liu, Yichuan; Sun, Xi-Zhuo; Qu, Jingchun; Fang, Zhang-Fu; Tian, Lifeng; Zeng, Yi-Feng; Huang, Shau-Ku; Hakonarson, Hakon; Liu, Zhi-Gang.

Wang EY; Shenzhen Key Laboratory of Allergy & Immunology, State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University School of Medicine, China.
Chen H; Department of Respirology & Allergy, Third Affiliated Hospital of Shenzhen University, China.
Sun BQ; Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang H; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, China.
Qu HQ; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, China.
Liu Y; Department of Medical Laboratory, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sun XZ; Center for Applied Genomics, The Children's Hospital of Philadelphia, PA, USA.
Qu J; Center for Applied Genomics, The Children's Hospital of Philadelphia, PA, USA.
Fang ZF; Department of Respirology & Allergy, Third Affiliated Hospital of Shenzhen University, China.
Tian L; Center for Applied Genomics, The Children's Hospital of Philadelphia, PA, USA.
Zeng YF; Shenzhen Key Laboratory of Allergy & Immunology, State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University School of Medicine, China.
Huang SK; Department of Respirology & Allergy, Third Affiliated Hospital of Shenzhen University, China.
Hakonarson H; Center for Applied Genomics, The Children's Hospital of Philadelphia, PA, USA.
Liu ZG; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, China.

FEBS Lett ; 595(13): 1819-1824, 2021 07.

Article Dans Anglais | MEDLINE | ID: covidwho-1220171

ABSTRACT

ABSTRACT

We previously observed enhanced immunoglobulin A (IgA) responses in severe COVID-19, which might confer damaging effects. Given the important role of IgA in immune and inflammatory responses, the aim of this study was to investigate the dynamic response of the IgA isotype switch factor TGF-ß1 in COVID-19 patients. We observed, in a total of 153 COVID-19 patients, that the serum levels of TGF-ß1 were increased significantly at the early and middle stages of COVID-19, and correlated with the levels of SARS-CoV-2-specific IgA, as well as with the APACHE II score in patients with severe disease. In view of the genetic association of the TGF-ß1 activator THBS3 with severe COVID-19 identified by the COVID-19 Host Genetics Initiative, this study suggests TGF-ß1 may play a key role in COVID-19.

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COVID-19; IgA; SARS-CoV-2; TGF-ß1

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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Sujet Principal: Immunoglobuline A / Thrombospondines / Facteur de croissance transformant bêta-1 / SARS-CoV-2 / COVID-19 Type d'étude: Étude pronostique Limites du sujet: Adulte / Adulte très âgé / Femelle / Humains / Mâle / Adulte d'âge moyen langue: Anglais Revue: FEBS Lett Année: 2021 Type de document: Article Pays d'affiliation: 1873-3468.14104

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