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Comparison of Blood Counts and Markers of Inflammation and Coagulation in Patients With and Without COVID-19 Presenting to the Emergency Department in Seattle, WA.
Chandler, Christopher M; Reid, Molly C; Cherian, Sindhu; Sabath, Daniel E; Edlefsen, Kerstin L.
  • Chandler CM; Departments of Laboratory Medicine and Pathology, Seattle, WA, USA.
  • Reid MC; Epidemiology, University of Washington, Seattle, WA, USA.
  • Cherian S; Departments of Laboratory Medicine and Pathology, Seattle, WA, USA.
  • Sabath DE; Departments of Laboratory Medicine and Pathology, Seattle, WA, USA.
  • Edlefsen KL; Departments of Laboratory Medicine and Pathology, Seattle, WA, USA.
Am J Clin Pathol ; 156(2): 185-197, 2021 07 06.
Article Dans Anglais | MEDLINE | ID: covidwho-1276141
ABSTRACT

OBJECTIVES:

We compared complete blood count (CBC) with differential and markers of inflammation and coagulation in patients with and without coronavirus disease 2019 (COVID-19) presenting to emergency departments in Seattle, WA.

METHODS:

We reviewed laboratory values for 1 week following each COVID-19 test for adult patients who received a standard severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) test before April 13, 2020. Results were compared by COVID-19 status and clinical course.

RESULTS:

In total 1,027 patients met inclusion criteria. Patients with COVID-19 (n = 155) had lower leukocytes (P < .0001), lymphocytes (P < .0001), platelets (P < .0001), and higher hemoglobin (P = .0140) than those without, but absolute differences were small. Serum albumin was lower in patients with COVID-19 (P < .0001) and serum albumin, neutrophil to lymphocyte ratio (NLR), and red cell distribution width (RDW) were each associated with disease severity. NLR did not differ between patients with COVID-19 and those without (P = .8012).

CONCLUSIONS:

Patients with COVID-19 had modestly lower leukocyte, lymphocyte, and platelet counts and higher hemoglobin values than patients without COVID-19. The NLR, serum albumin, and RDW varied with disease severity, regardless of COVID-19 status.
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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Sujet Principal: Hémogramme / Coagulation sanguine / Lymphocytes / COVID-19 / Inflammation Type d'étude: Étude diagnostique / Étude pronostique Limites du sujet: Adulte / Humains / Mâle / Adulte d'âge moyen langue: Anglais Revue: Am J Clin Pathol Année: 2021 Type de document: Article Pays d'affiliation: Ajcp

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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Sujet Principal: Hémogramme / Coagulation sanguine / Lymphocytes / COVID-19 / Inflammation Type d'étude: Étude diagnostique / Étude pronostique Limites du sujet: Adulte / Humains / Mâle / Adulte d'âge moyen langue: Anglais Revue: Am J Clin Pathol Année: 2021 Type de document: Article Pays d'affiliation: Ajcp