Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.

Dan, Jennifer M; Mateus, Jose; Kato, Yu; Hastie, Kathryn M; Yu, Esther Dawen; Faliti, Caterina E; Grifoni, Alba; Ramirez, Sydney I; Haupt, Sonya; Frazier, April; Nakao, Catherine; Rayaprolu, Vamseedhar; Rawlings, Stephen A; Peters, Bjoern; Krammer, Florian; Simon, Viviana; Saphire, Erica Ollmann; Smith, Davey M; Weiskopf, Daniela; Sette, Alessandro; Crotty, Shane

Dan, Jennifer M; Mateus, Jose; Kato, Yu; Hastie, Kathryn M; Yu, Esther Dawen; Faliti, Caterina E; Grifoni, Alba; Ramirez, Sydney I; Haupt, Sonya; Frazier, April; Nakao, Catherine; Rayaprolu, Vamseedhar; Rawlings, Stephen A; Peters, Bjoern; Krammer, Florian; Simon, Viviana; Saphire, Erica Ollmann; Smith, Davey M; Weiskopf, Daniela; Sette, Alessandro; Crotty, Shane.

Dan JM; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Mateus J; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
Kato Y; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Hastie KM; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Yu ED; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Faliti CE; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Grifoni A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Ramirez SI; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Haupt S; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Frazier A; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
Nakao C; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Rayaprolu V; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Rawlings SA; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Peters B; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Krammer F; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
Simon V; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Saphire EO; Department of Medicine, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
Smith DM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Weiskopf D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Sette A; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Crotty S; The Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Science ; 371(6529)2021 02 05.

Article Dans Anglais | MEDLINE | ID: covidwho-1309798

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ABSTRACT

ABSTRACT

Understanding immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics and vaccines and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥6 months after infection. Immunoglobulin G (IgG) to the spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month after symptom onset. SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3 to 5 months. By studying antibody, memory B cell, CD4+ T cell, and CD8+ T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.

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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Sujet Principal: COVID-19 / Mémoire immunologique / Anticorps antiviraux Type d'étude: Étude de cohorte / Étude observationnelle / Étude pronostique / Essai contrôlé randomisé Les sujets: Vaccins Limites du sujet: Adulte / Adulte très âgé / Femelle / Humains / Mâle / Adulte d'âge moyen / Jeune adulte Pays comme sujet: Amérique du Nord langue: Anglais Année: 2021 Type de document: Article Pays d'affiliation: Science.abf4063

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