Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil.

Penetra, Stephanie L S; da Silva, Michele F B; Resende, Paola; Pina-Costa, Anielle; Santos, Heloisa F P; Guaraldo, Lusiele; Calvet, Guilherme A; Ogrzewalska, Maria; Arantes, Ighor; Zukeram, Ketiuce; de Araújo, Mia F; Lima, Ana Beatriz Machado; Lopes, Renata Serrano; Lira-Silva, Larissa R; Moraes, Isabella V; Wakimoto, Mayumi D; Fuller, Trevon L; Gabaglia, Claudia Raja; Espíndola, Otávio M; Bonaldo, Myrna C; Daniel-Ribeiro, Cláudio Tadeu; Whitworth, Jimmy; Smith, Chris; Nielsen-Saines, Karin; Pauvolid-Correa, Alex; Siqueira, Marilda M; Brasil, Patricia

Penetra, Stephanie L S; da Silva, Michele F B; Resende, Paola; Pina-Costa, Anielle; Santos, Heloisa F P; Guaraldo, Lusiele; Calvet, Guilherme A; Ogrzewalska, Maria; Arantes, Ighor; Zukeram, Ketiuce; de Araújo, Mia F; Lima, Ana Beatriz Machado; Lopes, Renata Serrano; Lira-Silva, Larissa R; Moraes, Isabella V; Wakimoto, Mayumi D; Fuller, Trevon L; Gabaglia, Claudia Raja; Espíndola, Otávio M; Bonaldo, Myrna C; Daniel-Ribeiro, Cláudio Tadeu; Whitworth, Jimmy; Smith, Chris; Nielsen-Saines, Karin; Pauvolid-Correa, Alex; Siqueira, Marilda M; Brasil, Patricia.

Penetra SLS; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
da Silva MFB; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Resende P; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Pina-Costa A; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil; Serra dos Órgãos Education Foundation, Avenida Alberto Tôrres, 111 - Alto, Teresópolis, RJ, 25964-004, Brazil.
Santos HFP; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Guaraldo L; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Calvet GA; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Ogrzewalska M; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Arantes I; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Zukeram K; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
de Araújo MF; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Lima ABM; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Lopes RS; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Lira-Silva LR; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Moraes IV; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Wakimoto MD; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Fuller TL; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil; University of California, Los Angeles (UCLA), Box 951752, 10833 Le Conte Avenue 22-442 MDCC, Los Angeles, CA, 90095-1752, USA.
Gabaglia CR; Biomedical Research Institute of Southern California (BRISC), 4263 Oceanside Blvd#106-159, Oceanside, CA, 92056, USA.
Espíndola OM; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Bonaldo MC; Laboratory of Molecular Biology, Oswaldo Cruz Institute, Fiocruz, Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ 21040-3608, Brazil.
Daniel-Ribeiro CT; Department of Immunology, Oswaldo Cruz Institute, Fiocruz, Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Whitworth J; Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom.
Smith C; Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom.
Nielsen-Saines K; University of California, Los Angeles (UCLA), Box 951752, 10833 Le Conte Avenue 22-442 MDCC, Los Angeles, CA, 90095-1752, USA.
Pauvolid-Correa A; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil; T
Siqueira MM; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
Brasil P; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil. Electronic address: patricia.brasil@ini.fiocruz.br.

Int J Infect Dis ; 114: 58-61, 2022 Jan.

Article Dans Anglais | MEDLINE | ID: covidwho-1487754

ABSTRACT

ABSTRACT

We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in convalescent serum samples. Considering the permanent exposure of this healthcare worker to SARS-CoV-2, the waning immunity after the first infection, the low efficacy of the inactivated vaccine at preventing COVID-19, the immune escape of the Gamma variant (VOC), and the burden of post-COVID syndrome, this individual would have benefited from an additional dose of a heterologous vaccine.

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COVID-19 breakthrough infection; SARS-CoV-2 variants; health personnel; post-acute COVID-19 syndrome; reinfection; whole-genome sequencing

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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Sujet Principal: SARS-CoV-2 / COVID-19 Type d'étude: Rapport de cas Les sujets: Covid long / Vaccins / Variantes Limites du sujet: Humains Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Revue: Int J Infect Dis Thème du journal: Maladies transmissibles Année: 2022 Type de document: Article Pays d'affiliation: J.ijid.2021.10.048

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