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Adaptation, spread and transmission of SARS-CoV-2 in farmed minks and associated humans in the Netherlands.
Lu, Lu; Sikkema, Reina S; Velkers, Francisca C; Nieuwenhuijse, David F; Fischer, Egil A J; Meijer, Paola A; Bouwmeester-Vincken, Noortje; Rietveld, Ariene; Wegdam-Blans, Marjolijn C A; Tolsma, Paulien; Koppelman, Marco; Smit, Lidwien A M; Hakze-van der Honing, Renate W; van der Poel, Wim H M; van der Spek, Arco N; Spierenburg, Marcel A H; Molenaar, Robert Jan; Rond, Jan de; Augustijn, Marieke; Woolhouse, Mark; Stegeman, J Arjan; Lycett, Samantha; Oude Munnink, Bas B; Koopmans, Marion P G.
  • Lu L; Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Sikkema RS; Erasmus MC, Department of Viroscience, WHO Collaborating Centre, Rotterdam, the Netherlands.
  • Velkers FC; Department Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
  • Nieuwenhuijse DF; Erasmus MC, Department of Viroscience, WHO Collaborating Centre, Rotterdam, the Netherlands.
  • Fischer EAJ; Department Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
  • Meijer PA; Department Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
  • Bouwmeester-Vincken N; Municipal Health Service GGD Limburg-Noord, Venlo, the Netherlands.
  • Rietveld A; Municipal Health Service GGD Hart voor Brabant, Tilburg, the Netherlands.
  • Wegdam-Blans MCA; Stichting PAMM, Veldhoven, the Netherlands.
  • Tolsma P; Municipal Health Service GGD Brabant-Zuidoost, Eindhoven, the Netherlands.
  • Koppelman M; Sanquin Blood Supply Foundation, Amsterdam, the Netherlands.
  • Smit LAM; Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the Netherlands.
  • Hakze-van der Honing RW; Wageningen Bioveterinary Research, Lelystad, the Netherlands.
  • van der Poel WHM; Wageningen Bioveterinary Research, Lelystad, the Netherlands.
  • van der Spek AN; Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, the Netherlands.
  • Spierenburg MAH; Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, the Netherlands.
  • Molenaar RJ; GD Animal Health, Deventer, the Netherlands.
  • Rond J; GD Animal Health, Deventer, the Netherlands.
  • Augustijn M; GD Animal Health, Deventer, the Netherlands.
  • Woolhouse M; Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Stegeman JA; Department Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
  • Lycett S; Roslin Institute, University of Edinburgh, Edinburgh, UK.
  • Oude Munnink BB; Erasmus MC, Department of Viroscience, WHO Collaborating Centre, Rotterdam, the Netherlands.
  • Koopmans MPG; Erasmus MC, Department of Viroscience, WHO Collaborating Centre, Rotterdam, the Netherlands. m.koopmans@erasmusmc.nl.
Nat Commun ; 12(1): 6802, 2021 11 23.
Article Dans Anglais | MEDLINE | ID: covidwho-1532052
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
In the first wave of the COVID-19 pandemic (April 2020), SARS-CoV-2 was detected in farmed minks and genomic sequencing was performed on mink farms and farm personnel. Here, we describe the outbreak and use sequence data with Bayesian phylodynamic methods to explore SARS-CoV-2 transmission in minks and humans on farms. High number of farm infections (68/126) in minks and farm workers (>50% of farms) were detected, with limited community spread. Three of five initial introductions of SARS-CoV-2 led to subsequent spread between mink farms until November 2020. Viruses belonging to the largest cluster acquired an amino acid substitution in the receptor binding domain of the Spike protein (position 486), evolved faster and spread longer and more widely. Movement of people and distance between farms were statistically significant predictors of virus dispersal between farms. Our study provides novel insights into SARS-CoV-2 transmission between mink farms and highlights the importance of combining genetic information with epidemiological information when investigating outbreaks at the animal-human interface.
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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Sujet Principal: Évolution moléculaire / Fermes / SARS-CoV-2 / COVID-19 / Visons Type d'étude: Étude observationnelle / Étude pronostique / Essai contrôlé randomisé Limites du sujet: Animaux / Humains Pays comme sujet: Europe langue: Anglais Revue: Nat Commun Thème du journal: Biologie / Science Année: 2021 Type de document: Article Pays d'affiliation: S41467-021-27096-9

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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Sujet Principal: Évolution moléculaire / Fermes / SARS-CoV-2 / COVID-19 / Visons Type d'étude: Étude observationnelle / Étude pronostique / Essai contrôlé randomisé Limites du sujet: Animaux / Humains Pays comme sujet: Europe langue: Anglais Revue: Nat Commun Thème du journal: Biologie / Science Année: 2021 Type de document: Article Pays d'affiliation: S41467-021-27096-9