A Deep Look Into COVID-19 Severity Through Dynamic Changes in Blood Cytokine Levels.
Front Immunol
; 12: 771609, 2021.
Article
Dans Anglais
| MEDLINE | ID: covidwho-1551509
ABSTRACT
An excessive inflammatory response to SARS-CoV-2 is thought to be a major cause of disease severity and mortality in patients with COVID-19. Longitudinal analysis of cytokine release can expand our understanding of the initial stages of disease development and help to identify early markers serving as predictors of disease severity. In this study, we performed a comprehensive analysis of 46 cytokines (including chemokines and growth factors) in the peripheral blood of a large cohort of COVID-19 patients (n=444). The patients were classified into five severity groups. Longitudinal analysis of all patients revealed two groups of cytokines, characterizing the "early" and "late" stages of the disease course and the switch between type 1 and type 2 immunity. We found significantly increased levels of cytokines associated with different severities of COVID-19, and levels of some cytokines were significantly higher during the first three days from symptom onset (DfSO) in patients who eventually required intensive care unit (ICU) therapy. Additionally, we identified nine cytokines, TNF-α, IL-10, MIG, IL-6, IP-10, M-CSF, G-CSF, GM-CSF, and IFN-α2, that can be used as good predictors of ICU requirement at 4-6 DfSO.
Mots clés
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Indice de gravité de la maladie
/
Cytokines
/
Syndrome de libération de cytokines
/
SARS-CoV-2
/
COVID-19
/
Anticorps antiviraux
Type d'étude:
Étude de cohorte
/
Études expérimentales
/
Étude observationnelle
/
Étude pronostique
/
Essai contrôlé randomisé
Les sujets:
Covid long
Limites du sujet:
Femelle
/
Humains
/
Mâle
/
Adulte d'âge moyen
langue:
Anglais
Revue:
Front Immunol
Année:
2021
Type de document:
Article
Pays d'affiliation:
Fimmu.2021.771609
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS