Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort
Innovation in Aging
; 5(Supplement_1):344-345, 2021.
Article
Dans Anglais
| PMC | ID: covidwho-1584623
ABSTRACT
Hospitalized COVID-19 patients tend to be older and frequently have hypertension, diabetes or CHD, but whether these co-morbidities are more common than in the general older population is unclear. We estimated associations between pre-existing diagnoses and hospitalized COVID-19 alone or with mortality (during the first COVID-19 outbreak, tests performed between March 16 and April 26, 2020). In 269,070 UK Biobank participants aged 65+, 507 (0.2%) became COVID-19 hospital inpatients, of which 141 (27.8%) died. Common preexisting co-morbidities in hospitalized inpatients were hypertension (59.6%), history of falls/fragility fractures (29.4%), CHD (21.5%), T2 diabetes (19. 9%) and asthma (17.6%). However, in adjusted models, pre-existing diagnoses of dementia, T2 diabetes, COPD, pneumonia, depression, atrial fibrillation and hypertension emerged as independent risk factors for COVID-19 hospitalization, the first five remaining statistically significant for related mortality. There are specific high risk pre-existing co-morbidities for COVID-19 hospitalization and deaths in community based older men and women.
Texte intégral:
Disponible
Collection:
Bases de données des oragnisations internationales
Base de données:
PMC
Type d'étude:
Étude de cohorte
/
Étude observationnelle
/
Étude pronostique
langue:
Anglais
Revue:
Innovation in Aging
Année:
2021
Type de document:
Article
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