A European pharmacotherapeutic agent roflumilast exploring integrated preclinical and clinical evidence for SARS CoV-2 mediated inflammation to organ damage.
Br J Clin Pharmacol
; 88(8): 3562-3565, 2022 08.
Article
Dans Anglais
| MEDLINE | ID: covidwho-1764882
ABSTRACT
COVID-19 has spread globally, affecting almost 160 million individuals. Elderly and pre-existing patients (such as diabetes, heart disease and asthma) seem more susceptible to severe illness with COVID-19. Roflumilast was licensed for usage in the European Union in July 2010 as a phosphodiesterase-4 (PDE4) inhibitor. Under preclinical studies, roflumilast has been shown to decrease bleomycin-induced lung fibrosis, lung hydroxyproline and right heart thickening. The current study reviewed existing data that the PDE-4 inhibitor, a roflumilast, protects renal tissues and other major organ systems after COVID-19 infection by decreasing immune cell infiltration. These immune-balancing effects of roflumilast were related to a decrease in oxidative and inflammatory burden, caspase-3 suppression and increased protein kinase A (PKA)/cyclic A.M.P. (cAMP) levels in renal and other organ tissue.
Mots clés
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Inhibiteurs de la phosphodiestérase-4
/
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte très âgé
/
Humains
langue:
Anglais
Revue:
Br J Clin Pharmacol
Année:
2022
Type de document:
Article
Pays d'affiliation:
Bcp.15328
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