Risk Factors for Slow Viral Decline in COVID-19 Patients during the 2022 Omicron Wave.
Viruses
; 14(8)2022 08 04.
Article
Dans Anglais
| MEDLINE | ID: covidwho-1969516
ABSTRACT
Formulating termination of isolation (de-isolation) policies requires up-to-date knowledge about viral shedding dynamics. However, current de-isolation policies are largely based on viral load data obtained before the emergence of Omicron variant. In this retrospective cohort study involving adult patients hospitalised for COVID-19 between January and February 2022, we sought to determine SARS-CoV-2 viral shedding kinetics and to investigate the risk factors associated with slow viral decline during the 2022 Omicron wave. A total of 104 patients were included. The viral load was highest (Ct value was lowest) on days 1 post-symptom-onset (PSO) and gradually declined. Older age, hypertension, hyperlipidaemia and chronic kidney disease were associated with slow viral decline in the univariate analysis on both day 7 and day 10 PSO, while incomplete or no vaccination was associated with slow viral decline on day 7 PSO only. However, older age was the only risk factor that remained statistically significant in the multivariate analysis. In conclusion, older age is an independent risk factor associated with slow viral decline in this study conducted during the Omicron-dominant 2022 COVID-19 wave. Transmission-based precaution guidelines should take age into consideration when determining the timing of de-isolation.
Mots clés
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Excrétion virale
/
Charge virale
/
COVID-19
Type d'étude:
Étude de cohorte
/
Étude observationnelle
/
Étude pronostique
Les sujets:
Vaccins
/
Variantes
Limites du sujet:
Adulte
/
Adulte très âgé
/
Humains
langue:
Anglais
Année:
2022
Type de document:
Article
Pays d'affiliation:
V14081714
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