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Incidence and prevalence of coma in the UK and the USA.
Kondziella, Daniel; Amiri, Moshgan; Othman, Marwan H; Beghi, Ettore; Bodien, Yelena G; Citerio, Giuseppe; Giacino, Joseph T; Mayer, Stephan A; Lawson, Thomas N; Menon, David K; Rass, Verena; Sharshar, Tarek; Stevens, Robert D; Tinti, Lorenzo; Vespa, Paul; McNett, Molly; Venkatasubba Rao, Chethan P; Helbok, Raimund.
  • Kondziella D; Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
  • Amiri M; Department of Clinical Medicine, University of Copenhagen, Copenhagen 2100, Denmark.
  • Othman MH; Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
  • Beghi E; Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
  • Bodien YG; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan 20156, Italy.
  • Citerio G; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Giacino JT; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Mayer SA; NeuroIntensive Care, ASST di Monza, Monza 20900, Italy.
  • Lawson TN; School of Medicine and Surgery, Università Milano Bicocca, Milan 20100, Italy.
  • Menon DK; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Rass V; Department of Neurology, New York Medical College, Valhalla, NY 10595, USA.
  • Sharshar T; College of Nursing, The Ohio State University, Columbus, OH 43210, USA.
  • Stevens RD; Division of Anaesthesia, University of Cambridge, Cambridge CB2 2QQ, UK.
  • Tinti L; Department of Neurology, Neuro-Intensive Care Unit, Medical University of Innsbruck, Innsbruck 6020, Austria.
  • Vespa P; Neuro-anesthesiology and Intensive Care Medicine, Sainte-Anne Hospital, Paris-Descartes University, Paris 75006, France.
  • McNett M; Experimental Neuropathology, Infection and Epidemiology Department, Institut Pasteur, Paris 75015, France.
  • Venkatasubba Rao CP; Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Helbok R; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA.
Brain Commun ; 4(5): fcac188, 2022.
Article Dans Anglais | MEDLINE | ID: covidwho-2017748
ABSTRACT
The epidemiology of coma is unknown because case ascertainment with traditional methods is difficult. Here, we used crowdsourcing methodology to estimate the incidence and prevalence of coma in the UK and the USA. We recruited UK and US laypeople (aged ≥18 years) who were nationally representative (i.e. matched for age, gender and ethnicity according to census data) of the UK and the USA, respectively, utilizing a crowdsourcing platform. We provided a description of coma and asked survey participants if they-'right now' or 'within the last year'-had a family member in coma. These participants (UK n = 994, USA n = 977) provided data on 30 387 family members (UK n = 14 124, USA n = 16 263). We found more coma cases in the USA (n = 47) than in the UK (n = 20; P = 0.009). We identified one coma case in the UK (0.007%, 95% confidence interval 0.00-0.04%) on the day of the survey and 19 new coma cases (0.13%, 95% confidence interval 0.08-0.21%) within the preceding year, resulting in an annual incidence of 135/100 000 (95% confidence interval 81-210) and a point prevalence of 7 cases per 100 000 population (95% confidence interval 0.18-39.44) in the UK. We identified five cases in the USA (0.031%, 95% confidence interval 0.01-0.07%) on the day of the survey and 42 new cases (0.26%, 95% confidence interval 0.19-0.35%) within the preceding year, resulting in an annual incidence of 258/100 000 (95% confidence interval 186-349) and a point prevalence of 31 cases per 100 000 population (95% confidence interval 9.98-71.73) in the USA. The five most common causes were stroke, medically induced coma, COVID-19, traumatic brain injury and cardiac arrest. To summarize, for the first time, we report incidence and prevalence estimates for coma across diagnosis types and settings in the UK and the USA using crowdsourcing methods. Coma may be more prevalent in the USA than in the UK, which requires further investigation. These data are urgently needed to expand the public health perspective on coma and disorders of consciousness.
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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Type d'étude: Étude observationnelle langue: Anglais Revue: Brain Commun Année: 2022 Type de document: Article Pays d'affiliation: Braincomms

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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Type d'étude: Étude observationnelle langue: Anglais Revue: Brain Commun Année: 2022 Type de document: Article Pays d'affiliation: Braincomms