Effects of different mucosal adjuvants on the immune responses induced by porcine deltacoronavirus in mice
Acta Microbiologica Sinica
; 7(23), 2022.
Article
Dans Chinois
| CAB Abstracts | ID: covidwho-2025659
ABSTRACT
Objective:
The aim of this study is to screen an ideal adjuvant for an inactivated porcine deltacoronavirus(PDCoV) vaccine to induce mucosal immunity and reduce the side effect of the vaccine. We used different mucosal adjuvants to prepare the inactivated PDCoV vaccines. We then used mouse model to evaluate the humoral, cellular and mucosal immune responses induced by the inactivated vaccines via different immunization routes.
Host Resistance and Immunity [HH600]; Laboratory Animal Science [LL040]; Prion, Viral, Bacterial and Fungal Pathogens of Animals [LL821]; Animal Immunology [LL650]; animal models; laboratory animals; adjuvants; immune response; IgG; immunization; vaccines; gene expression; interleukin 4; vaccine development; disease prevention; disease control; mucosa; immunity; ELISA; interferon-gamma; inactivated vaccines; immune sensitization; mice; Porcine deltacoronavirus; Muridae; rodents; mammals; vertebrates; Chordata; animals; eukaryotes; Deltacoronavirus; Orthocoronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; immunity reactions; immunological reactions; mucous membrane; enzyme linked immunosorbent assay; killed vaccines
Texte intégral:
Disponible
Collection:
Bases de données des oragnisations internationales
Base de données:
CAB Abstracts
Type d'étude:
Études expérimentales
langue:
Chinois
Revue:
Acta Microbiologica Sinica
Année:
2022
Type de document:
Article
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