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A decoy microrobot that removes SARS-CoV-2 and its variants in wastewater.
Lai, Jialin; Meng, Qian-Fang; Tian, Mingyao; Zhuang, Xinyu; Pan, Pan; Du, Liang; Deng, Lin; Tang, Jinyao; Jin, Ningyi; Rao, Lang.
  • Lai J; Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen 518132, China.
  • Meng QF; Department of Chemistry, The University of Hong Kong, Hong Kong 999077, China.
  • Tian M; Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen 518132, China.
  • Zhuang X; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
  • Pan P; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
  • Du L; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Deng L; School of Physics and Technology, Wuhan University, Wuhan 430072, China.
  • Tang J; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518132, China.
  • Jin N; Department of Chemistry, The University of Hong Kong, Hong Kong 999077, China.
  • Rao L; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Cell Rep Phys Sci ; 3(10): 101061, 2022 Oct 19.
Article Dans Anglais | MEDLINE | ID: covidwho-2042210
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can persist in wastewater for several days, has a risk of waterborne-human transmission. The emergence of SARS-CoV-2 variants with increased infection capacity further highlights the need to remove the virus and restrict its spread in wastewater. Here, we report a decoy microrobot created by camouflaging algae with cell membranes displaying angiotensin-converting enzyme 2 (ACE2) for effective elimination of SARS-CoV-2 and its variants. The decoy microrobots show fast self-propulsion (>85 µm/s), allowing for successful "on-the-fly" elimination of SARS-CoV-2 spike proteins and pseudovirus in wastewater. Moreover, relying on the robust binding between ACE2 and SARS-CoV-2 variants, the decoy microrobots exhibit a broad-spectrum elimination of virus with a high efficiency of 95% for the wild-type strain, 92% for the Delta variant, and 93% for the Omicron variant, respectively. Our work presents a simple and safe decoy microrobot aimed toward eliminating viruses and other environmental hazards from wastewater.
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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Type d'étude: Étude pronostique Les sujets: Variantes langue: Anglais Revue: Cell Rep Phys Sci Année: 2022 Type de document: Article Pays d'affiliation: J.xcrp.2022.101061

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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Type d'étude: Étude pronostique Les sujets: Variantes langue: Anglais Revue: Cell Rep Phys Sci Année: 2022 Type de document: Article Pays d'affiliation: J.xcrp.2022.101061