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Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium.
de Erausquin, Gabriel A; Snyder, Heather; Brugha, Traolach S; Seshadri, Sudha; Carrillo, Maria; Sagar, Rajesh; Huang, Yueqin; Newton, Charles; Tartaglia, Carmela; Teunissen, Charlotte; Håkanson, Krister; Akinyemi, Rufus; Prasad, Kameshwar; D'Avossa, Giovanni; Gonzalez-Aleman, Gabriela; Hosseini, Akram; Vavougios, George D; Sachdev, Perminder; Bankart, John; Mors, Niels Peter Ole; Lipton, Richard; Katz, Mindy; Fox, Peter T; Katshu, Mohammad Zia; Iyengar, M Sriram; Weinstein, Galit; Sohrabi, Hamid R; Jenkins, Rachel; Stein, Dan J; Hugon, Jacques; Mavreas, Venetsanos; Blangero, John; Cruchaga, Carlos; Krishna, Murali; Wadoo, Ovais; Becerra, Rodrigo; Zwir, Igor; Longstreth, William T; Kroenenberg, Golo; Edison, Paul; Mukaetova-Ladinska, Elizabeta; Staufenberg, Ekkehart; Figueredo-Aguiar, Mariana; Yécora, Agustín; Vaca, Fabiana; Zamponi, Hernan P; Re, Vincenzina Lo; Majid, Abdul; Sundarakumar, Jonas; Gonzalez, Hector M.
  • de Erausquin GA; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases Joe and Teresa Long School of Medicine University of Texas Health San Antonio San Antonio Texas USA.
  • Snyder H; Alzheimer's Association Chicago Illinois USA.
  • Brugha TS; University of Leicester Leicester UK.
  • Seshadri S; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases Joe and Teresa Long School of Medicine University of Texas Health San Antonio San Antonio Texas USA.
  • Carrillo M; Alzheimer's Association Chicago Illinois USA.
  • Sagar R; All India Institute of Medical Sciences New Delhi India.
  • Huang Y; Peking University Sixth Hospital Beijing China.
  • Newton C; Medical Sciences Division University of Oxford Oxford UK.
  • Tartaglia C; University of Toronto Toronto Ontario Canada.
  • Teunissen C; Amsterdam UMC Locatie AMC Amsterdam the Netherlands.
  • Håkanson K; Karolinska Institute Solna Sweden.
  • Akinyemi R; University of Ibadan Ibadan Nigeria.
  • Prasad K; All India Institute of Medical Sciences New Delhi India.
  • D'Avossa G; Bangor University Bangor UK.
  • Gonzalez-Aleman G; Pontificia Universidad Católica Argentina Santa María de los Buenos Aires Ciudad Autónoma de Buenos Aires Argentina.
  • Hosseini A; University of Nottingham Nottingham UK.
  • Vavougios GD; University of Thessaly Larissa Greece.
  • Sachdev P; University of New South Wales Sydney New South Wales Australia.
  • Bankart J; University of Leicester Leicester UK.
  • Mors NPO; Aarhus University Aarhus Denmark.
  • Lipton R; Albert Einstein College of Medicine New York New York USA.
  • Katz M; Albert Einstein College of Medicine New York New York USA.
  • Fox PT; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases Joe and Teresa Long School of Medicine University of Texas Health San Antonio San Antonio Texas USA.
  • Katshu MZ; University of Nottingham Nottingham UK.
  • Iyengar MS; University of Arizona Health Sciences Center Tucson Arizona USA.
  • Weinstein G; University of Haifa Haifa Israel.
  • Sohrabi HR; Centre for Healthy Ageing Murdoch University Murdoch Western Australia Australia.
  • Jenkins R; Institute of Psychiatry King's College London London UK.
  • Stein DJ; University of Cape Town Cape Town South Africa.
  • Hugon J; Université de Paris Cité Faculté de Médecine Paris France.
  • Mavreas V; University of Ioannina Faculty of Medicine Ioannina Greece.
  • Blangero J; Institute of Neuroscience University of Texas Rio Grande Valley Harlingen Texas USA.
  • Cruchaga C; Washington University School of Medicine Saint Louis Missouri USA.
  • Krishna M; Foundation for Research and Advocacy in Mental Health and Viveka Hospital Mysore India.
  • Wadoo O; Hamad Medical Corporation Doha Qatar.
  • Becerra R; University of Western Australia Perth Western Australia Australia.
  • Zwir I; Washington University School of Medicine Saint Louis Missouri USA.
  • Longstreth WT; University of Washington Seattle Washington USA.
  • Kroenenberg G; University of Zurich Zurich Switzerland.
  • Edison P; Imperial College London London UK.
  • Mukaetova-Ladinska E; University of Leicester Leicester UK.
  • Staufenberg E; Hertfordshire Partnership University NHS Foundation Trust Hertfordshire UK.
  • Figueredo-Aguiar M; Fundación de Lucha contra los Trastornos Neurológicos y Psiquiátricos en Minorías (FULTRA) Ciudad Autónoma de Buenos Aires Argentina.
  • Yécora A; Ministerio de Salud de la Provincia de Jujuy San Salvador de Jujuy Argentina.
  • Vaca F; Ministerio de Salud de la Provincia de Jujuy San Salvador de Jujuy Argentina.
  • Zamponi HP; Ministerio de Salud de la Provincia de Jujuy San Salvador de Jujuy Argentina.
  • Re VL; Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione Istituto di Ricovero e Cura a Carattere Scientifico (ISMETT-IRRCS) Palermo Italy.
  • Majid A; Sher-i-Kashmir Institute of Medical Sciences (SKIMS) Srinagar India.
  • Sundarakumar J; Indian Institute of Science Bengaluru India.
  • Gonzalez HM; University of California San Diego San Diego California USA.
Alzheimers Dement (N Y) ; 8(1): e12348, 2022.
Article Dans Anglais | MEDLINE | ID: covidwho-2047953
ABSTRACT

Introduction:

Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID-19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity of the original pulmonary illness. It behooves the scientific and medical community to attempt to understand the molecular and/or systemic factors linking COVID-19 to neurologic illness, both short and long term.

Methods:

This article describes what is known so far in terms of links among COVID-19, the brain, neurological symptoms, and Alzheimer's disease (AD) and related dementias. We focus on risk factors and possible molecular, inflammatory, and viral mechanisms underlying neurological injury. We also provide a comprehensive description of the Alzheimer's Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) harmonized methodology to address these questions using a worldwide network of researchers and institutions.

Results:

Successful harmonization of designs and methods was achieved through a consensus process initially fragmented by specific interest groups (epidemiology, clinical assessments, cognitive evaluation, biomarkers, and neuroimaging). Conclusions from subcommittees were presented to the whole group and discussed extensively. Presently data collection is ongoing at 19 sites in 12 countries representing Asia, Africa, the Americas, and Europe.

Discussion:

The Alzheimer's Association Global Consortium harmonized methodology is proposed as a model to study long-term neurocognitive sequelae of SARS-CoV-2 infection. Key Points The following review describes what is known so far in terms of molecular and epidemiological links among COVID-19, the brain, neurological symptoms, and AD and related dementias (ADRD)The primary objective of this large-scale collaboration is to clarify the pathogenesis of ADRD and to advance our understanding of the impact of a neurotropic virus on the long-term risk of cognitive decline and other CNS sequelae. No available evidence supports the notion that cognitive impairment after SARS-CoV-2 infection is a form of dementia (ADRD or otherwise). The longitudinal methodologies espoused by the consortium are intended to provide data to answer this question as clearly as possible controlling for possible confounders. Our specific hypothesis is that SARS-CoV-2 triggers ADRD-like pathology following the extended olfactory cortical network (EOCN) in older individuals with specific genetic susceptibility.The proposed harmonization strategies and flexible study designs offer the possibility to include large samples of under-represented racial and ethnic groups, creating a rich set of harmonized cohorts for future studies of the pathophysiology, determinants, long-term consequences, and trends in cognitive aging, ADRD, and vascular disease.We provide a framework for current and future studies to be carried out within the Consortium. and offers a "green paper" to the research community with a very broad, global base of support, on tools suitable for low- and middle-income countries aimed to compare and combine future longitudinal data on the topic.The Consortium proposes a combination of design and statistical methods as a means of approaching causal inference of the COVID-19 neuropsychiatric sequelae. We expect that deep phenotyping of neuropsychiatric sequelae may provide a series of candidate syndromes with phenomenological and biological characterization that can be further explored. By generating high-quality harmonized data across sites we aim to capture both descriptive and, where possible, causal associations.
Mots clés

Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Type d'étude: Étude de cohorte / Études expérimentales / Étude observationnelle / Étude pronostique / Recherche qualitative / Essai contrôlé randomisé Les sujets: Covid long langue: Anglais Revue: Alzheimers Dement (N Y) Année: 2022 Type de document: Article

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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Type d'étude: Étude de cohorte / Études expérimentales / Étude observationnelle / Étude pronostique / Recherche qualitative / Essai contrôlé randomisé Les sujets: Covid long langue: Anglais Revue: Alzheimers Dement (N Y) Année: 2022 Type de document: Article