A fatal SARS-coronavirus-2 induced bone marrow aplasia complicated with invasive fungal infection and severe neutropenic enterocolitis.
BMC Infect Dis
; 22(1): 682, 2022 Aug 09.
Article
Dans Anglais
| MEDLINE | ID: covidwho-2214535
ABSTRACT
BACKGROUND:
Immunization against the coronavirus disease 2019 (COVID-19) began in January 2021 in Iran; nonetheless, due to a lack of vaccination among children under 12, this age group is still at risk of SARS-CoV-2 infection and its complications. CASE PRESENTATION SARS-CoV-2 infection was diagnosed in a 6-year-old girl who had previously been healthy but had developed a fever and pancytopenia. The bone marrow aspiration/biopsy demonstrated just hypocellular marrow without signs of leukemia. She was worked up for primary and secondary causes of pancytopenia. Except for a repeated reactive HIV antibody/Ag P24 assay, all test results were inconclusive. After a thorough diagnostic investigation, the cross-reactivity of the HIV antibody/Ag P24 test with SARS-CoV-2 antibodies was confirmed. The patient did not develop any COVID-19-related signs and symptoms, but she did get a severe invasive fungal infection and neutropenic enterocolitis. She died as a result of disseminated intravascular coagulopathy.CONCLUSION:
It is critical to recognize children infected with SARS-CoV-2 who exhibit atypical clinical manifestations of COVID-19, such as persistent pancytopenia. SARS-CoV-2 infection can cause severe and deadly consequences in children; thus, pediatricians should be aware of COVID-19's unusual signs and symptoms mimicking other conditions such as aplastic anemia.Mots clés
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Pancytopénie
/
Infections à VIH
/
Entérocolite du patient neutropénique
/
Infections fongiques invasives
/
COVID-19
/
Anémie aplasique
Type d'étude:
Rapport de cas
/
Étude diagnostique
/
Étude pronostique
/
Essai contrôlé randomisé
Les sujets:
Covid long
/
Vaccins
Limites du sujet:
Enfant
/
Femelle
/
Humains
langue:
Anglais
Revue:
BMC Infect Dis
Thème du journal:
Maladies transmissibles
Année:
2022
Type de document:
Article
Pays d'affiliation:
S12879-022-07599-6
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