Platelet-Neutrophil Crosstalk in Thrombosis.
Int J Mol Sci
; 24(2)2023 Jan 09.
Article
Dans Anglais
| MEDLINE | ID: covidwho-2233239
ABSTRACT
Platelets are essential for the formation of a haemostatic plug to prevent bleeding, while neutrophils are the guardians of our immune defences against invading pathogens. The interplay between platelets and innate immunity, and subsequent triggering of the activation of coagulation is part of the host system to prevent systemic spread of pathogen in the blood stream. Aberrant immunothrombosis and excessive inflammation can however, contribute to the thrombotic burden observed in many cardiovascular diseases. In this review, we highlight how platelets and neutrophils interact with each other and how their crosstalk is central to both arterial and venous thrombosis and in COVID-19. While targeting platelets and coagulation enables efficient antithrombotic treatments, they are often accompanied with a bleeding risk. We also discuss how novel approaches to reduce platelet-mediated recruitment of neutrophils could represent promising therapies to treat thrombosis without affecting haemostasis.
Mots clés
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Thrombose
/
Pièges extracellulaires
/
COVID-19
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Année:
2023
Type de document:
Article
Pays d'affiliation:
Ijms24021266
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