Extracellular Vesicles: New Players in the Mechanisms of Sepsis- and COVID-19-Related Thromboinflammation.
Int J Mol Sci
; 24(3)2023 Jan 18.
Article
Dans Anglais
| MEDLINE | ID: covidwho-2244966
ABSTRACT
Sepsis and COVID-19 patients often manifest an imbalance in inflammation and coagulation, a complex pathological mechanism also named thromboinflammation, which strongly affects patient prognosis. Extracellular vesicles (EVs) are nanoparticles released by cells into extracellular space that have a relevant role in cell-to-cell communication. Recently, EVs have been shown to act as important players in a variety of pathologies, including cancer and cardiovascular disease. The biological properties of EVs in the mechanisms of thromboinflammation during sepsis and COVID-19 are still only partially known. Herein, we summarize the current experimental evidence on the role of EVs in thromboinflammation, both in bacterial sepsis and in COVID-19. A better understanding of EV involvement in these processes could be useful in describing novel diagnostic and therapeutic applications of EVs in these diseases.
Mots clés
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Thrombose
/
Sepsie
/
Vésicules extracellulaires
/
COVID-19
Type d'étude:
Étude pronostique
Les sujets:
Covid long
Limites du sujet:
Humains
langue:
Anglais
Année:
2023
Type de document:
Article
Pays d'affiliation:
Ijms24031920
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