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Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine.
Qiu, Shaofu; Chen, Zhao; Zhu, Airu; Zeng, Qiuhui; Liu, Hongbo; Liu, Xiaoqing; Ye, Feng; Jin, Yingkang; Wu, Jie; Yang, Chaojie; Wang, Qi; Chen, Fangli; Chen, Lan; Tian, Sai; Du, Xinying; Hu, Qingtao; Cheng, Jinling; Chen, Canjie; Li, Fang; Sun, Jing; Wang, Yanqun; Zhao, Jingxian; Zhao, Jincun; Song, Hongbin.
  • Qiu S; The Chinese PLA Center for Disease Control and Prevention, 100071, Beijing, China.
  • Chen Z; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
  • Zhu A; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
  • Zeng Q; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
  • Liu H; The Chinese PLA Center for Disease Control and Prevention, 100071, Beijing, China.
  • Liu X; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
  • Ye F; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
  • Jin Y; Pediatric Pulmonary Department, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 510623, Guangzhou, Guangdong, China.
  • Wu J; Guangdong Provincial Center for Disease Control and Prevention, 510399, Guangzhou, Guangdong, China.
  • Yang C; The Chinese PLA Center for Disease Control and Prevention, 100071, Beijing, China.
  • Wang Q; The Chinese PLA Center for Disease Control and Prevention, 100071, Beijing, China.
  • Chen F; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
  • Chen L; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
  • Tian S; The Chinese PLA Center for Disease Control and Prevention, 100071, Beijing, China.
  • Du X; The Chinese PLA Center for Disease Control and Prevention, 100071, Beijing, China.
  • Hu Q; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
  • Cheng J; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
  • Chen C; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
  • Li F; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
  • Sun J; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
  • Wang Y; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
  • Zhao J; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China. zhaojingxian@gird.cn.
  • Zhao J; Guangzhou Laboratory, Bio-island, 510320, Guangzhou, Guangdong, China. zhaojingxian@gird.cn.
  • Song H; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China. zhaojincun@gird.cn.
Signal Transduct Target Ther ; 8(1): 123, 2023 03 15.
Article Dans Anglais | MEDLINE | ID: covidwho-2277246
ABSTRACT
Persistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we report a cohort of 23 PA cases carrying viral RNA for up to 191 days. PA cases displayed low levels of inflammatory and interferon response, weak antibody response, diminished circulating follicular helper T cells (cTfh), and inadequate specific CD4+ and CD8+ T-cell responses during infection, which is distinct from symptomatic infections and resembling impaired immune activation. Administration of a single dose of Ad5-nCoV vaccine to 10 of these PA cases elicited rapid and robust antibody responses as well as coordinated B-cell and cTfh responses, resulting in successful viral clearance. Vaccine-induced antibodies were able to neutralize various variants of concern and persisted for over 6 months, indicating long-term protection. Therefore, our study provides an insight into the immune status of PA infections and highlights vaccination as a potential treatment for prolonged SARS-CoV-2 infections.
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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Sujet Principal: COVID-19 Type d'étude: Étude de cohorte / Étude observationnelle / Étude pronostique Les sujets: Covid long / Vaccins / Variantes Limites du sujet: Humains langue: Anglais Revue: Signal Transduct Target Ther Année: 2023 Type de document: Article Pays d'affiliation: S41392-023-01345-3

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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Sujet Principal: COVID-19 Type d'étude: Étude de cohorte / Étude observationnelle / Étude pronostique Les sujets: Covid long / Vaccins / Variantes Limites du sujet: Humains langue: Anglais Revue: Signal Transduct Target Ther Année: 2023 Type de document: Article Pays d'affiliation: S41392-023-01345-3