COVID-19 and Older Adults: What We Know.
J Am Geriatr Soc
; 68(5): 926-929, 2020 05.
Article
Dans Anglais
| MEDLINE | ID: covidwho-2280768
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that causes COVID-19 infection, has recently emerged and caused a deadly pandemic. Studies have shown that this virus causes worse outcomes and a higher mortality rate in older adults and those with comorbidities such as hypertension, cardiovascular disease, diabetes, chronic respiratory disease, and chronic kidney disease (CKD). A significant percentage of older American adults have these diseases, putting them at a higher risk of infection. Additionally, many adults with hypertension, diabetes, and CKD are placed on angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers. Studies have shown that these medications upregulate the ACE-2 receptor, the very receptor that the SARS-CoV-2 virus uses to enter host cells. Although it has been hypothesized that this may cause a further increased risk of infection, more studies on the role of these medications in COVID-19 infections are necessary. In this review, we discuss the transmission, symptomatology, and mortality of COVID-19 as they relate to older adults, and possible treatments that are currently under investigation. J Am Geriatr Soc 68926-929, 2020.
Mots clés
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Pneumopathie virale
/
Infections à coronavirus
/
Pandémies
Type d'étude:
Étude diagnostique
/
Étude pronostique
/
Essai contrôlé randomisé
Limites du sujet:
Adulte très âgé
/
Humains
langue:
Anglais
Revue:
J Am Geriatr Soc
Année:
2020
Type de document:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS