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Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients.
Polonikov, Alexey.
  • Polonikov A; Department of Biology, Medical Genetics and Ecology and Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 3 Karl Marx Street, 305041 Kursk, Russian Federation.
ACS Infect Dis ; 6(7): 1558-1562, 2020 07 10.
Article Dans Anglais | MEDLINE | ID: covidwho-401389
Informations sémantiques de SemMedBD (par NLM)
1. COVID-19 PROCESS_OF Patients
Matière
COVID-19
Prédicat
PROCESS_OF
Objet
Patients
2. Cessation of life PROCESS_OF Patients
Matière
Cessation of life
Prédicat
PROCESS_OF
Objet
Patients
3. 2019 novel coronavirus PROCESS_OF Older people
Matière
2019 novel coronavirus
Prédicat
PROCESS_OF
Objet
Older people
4. Comorbidity PROCESS_OF Older people
Matière
Comorbidity
Prédicat
PROCESS_OF
Objet
Older people
5. Oxidative Stress AFFECTS Persons
Matière
Oxidative Stress
Prédicat
AFFECTS
Objet
Persons
6. COVID-19 PROCESS_OF Patients
Matière
COVID-19
Prédicat
PROCESS_OF
Objet
Patients
7. Cessation of life PROCESS_OF Patients
Matière
Cessation of life
Prédicat
PROCESS_OF
Objet
Patients
8. 2019 novel coronavirus PROCESS_OF Older people
Matière
2019 novel coronavirus
Prédicat
PROCESS_OF
Objet
Older people
9. Comorbidity PROCESS_OF Older people
Matière
Comorbidity
Prédicat
PROCESS_OF
Objet
Older people
10. Oxidative Stress AFFECTS Persons
Matière
Oxidative Stress
Prédicat
AFFECTS
Objet
Persons
ABSTRACT
Higher rates of serious illness and death from coronavirus SARS-CoV-2 (COVID-19) infection among older people and those who have comorbidities suggest that age- and disease-related biological processes make such individuals more sensitive to environmental stress factors including infectious agents like coronavirus SARS-CoV-2. Specifically, impaired redox homeostasis and associated oxidative stress appear to be important biological processes that may account for increased individual susceptibility to diverse environmental insults. The aim of this Viewpoint is to justify (1) the crucial roles of glutathione in determining individual responsiveness to COVID-19 infection and disease pathogenesis and (2) the feasibility of using glutathione as a means for the treatment and prevention of COVID-19 illness. The hypothesis that glutathione deficiency is the most plausible explanation for serious manifestation and death in COVID-19 patients was proposed on the basis of an exhaustive literature analysis and observations. The hypothesis unravels the mysteries of epidemiological data on the risk factors determining serious manifestations of COVID-19 infection and the high risk of death and opens real opportunities for effective treatment and prevention of the disease.
Sujets)

Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Type de document: Article Sujet Principal: Antiviraux / Pneumopathie virale / Infections à coronavirus / Betacoronavirus / Glutathion / Anti-inflammatoires / Anticoagulants / Antioxydants Type d'étude: Etude d'étiologie / Étude pronostique / Facteurs de risque langue: Anglais Revue: ACS Infect Dis Aspect clinique: Étiologie / Pronostic Année: 2020

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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Type de document: Article Sujet Principal: Antiviraux / Pneumopathie virale / Infections à coronavirus / Betacoronavirus / Glutathion / Anti-inflammatoires / Anticoagulants / Antioxydants Type d'étude: Etude d'étiologie / Étude pronostique / Facteurs de risque langue: Anglais Revue: ACS Infect Dis Aspect clinique: Étiologie / Pronostic Année: 2020
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