Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration?
Brain Behav Immun
; 89: 601-603, 2020 10.
Article
Dans Anglais
| MEDLINE | ID: covidwho-651618
ABSTRACT
We describe a man whose first manifestations of Creutzfeldt-Jakob disease occurred in tandem with symptomatic onset of coronavirus disease 2019 (COVID-19). Drawing from recent data on prion disease pathogenesis and immune responses to SARS-CoV-2, we hypothesize that the cascade of systemic inflammatory mediators in response to the virus accelerated the pathogenesis of our patient's prion disease. This hypothesis introduces the potential relationship between immune responses to the novel coronavirus and the hastening of preclinical or manifest neurodegenerative disorders. The global prevalence of both COVID-19 and neurodegenerative disorders adds urgency to the study of this potential relationship.
Mots clés
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Pneumopathie virale
/
Encéphale
/
Maladie de Creutzfeldt-Jakob
/
Infections à coronavirus
Type d'étude:
Rapport de cas
/
Étude diagnostique
/
Étude observationnelle
Les sujets:
Covid long
/
Variantes
Limites du sujet:
Adulte très âgé
/
Humains
/
Mâle
langue:
Anglais
Revue:
Brain Behav Immun
Thème du journal:
Allergie et immunologie
/
Cerveau
/
Psychophysiologie
Année:
2020
Type de document:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS