A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity.

Huang, Angkana T; Garcia-Carreras, Bernardo; Hitchings, Matt D T; Yang, Bingyi; Katzelnick, Leah C; Rattigan, Susan M; Borgert, Brooke A; Moreno, Carlos A; Solomon, Benjamin D; Trimmer-Smith, Luke; Etienne, Veronique; Rodriguez-Barraquer, Isabel; Lessler, Justin; Salje, Henrik; Burke, Donald S; Wesolowski, Amy; Cummings, Derek A T

Huang, Angkana T; Garcia-Carreras, Bernardo; Hitchings, Matt D T; Yang, Bingyi; Katzelnick, Leah C; Rattigan, Susan M; Borgert, Brooke A; Moreno, Carlos A; Solomon, Benjamin D; Trimmer-Smith, Luke; Etienne, Veronique; Rodriguez-Barraquer, Isabel; Lessler, Justin; Salje, Henrik; Burke, Donald S; Wesolowski, Amy; Cummings, Derek A T.

Huang AT; Department of Biology, University of Florida, Gainesville, FL, USA.
Garcia-Carreras B; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Hitchings MDT; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Yang B; Department of Biology, University of Florida, Gainesville, FL, USA.
Katzelnick LC; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Rattigan SM; Department of Biology, University of Florida, Gainesville, FL, USA.
Borgert BA; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Moreno CA; Department of Biology, University of Florida, Gainesville, FL, USA.
Solomon BD; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Trimmer-Smith L; Department of Biology, University of Florida, Gainesville, FL, USA.
Etienne V; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Rodriguez-Barraquer I; Department of Biology, University of Florida, Gainesville, FL, USA.
Lessler J; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Salje H; Department of Biology, University of Florida, Gainesville, FL, USA.
Burke DS; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Wesolowski A; Department of Biology, University of Florida, Gainesville, FL, USA.
Cummings DAT; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.

Nat Commun ; 11(1): 4704, 2020 09 17.

Article Dans Anglais | MEDLINE | ID: covidwho-779998

ABSTRACT

ABSTRACT

Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.

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Texte intégral: Disponible Collection: Bases de données internationales Base de données: MEDLINE Sujet Principal: Pneumopathie virale / Infections à coronavirus / Betacoronavirus / Anticorps antiviraux Type d'étude: Étude observationnelle / Étude pronostique / Essai contrôlé randomisé / Révision / Examen systématique/Méta-analyse Les sujets: Vaccins Limites du sujet: Humains langue: Anglais Revue: Nat Commun Thème du journal: Biologie / Science Année: 2020 Type de document: Article Pays d'affiliation: S41467-020-18450-4

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