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Confronting the COVID-19 Pandemic with Systems Biology
Erica Teixeira Prates; Michael R Garvin; Mirko Pavicic; Piet Jones; Manesh Shah; Christiane Alvarez; David Kainer; Omar Demerdash; B Kirtley Amos; Armin Geiger; Daniel Jacobson.
  • Erica Teixeira Prates; Oak Ridge National Laboratory
  • Michael R Garvin; Oak Ridge National Laboratory
  • Mirko Pavicic; Oak Ridge National Laboratory
  • Piet Jones; University of Tennessee Knoxville
  • Manesh Shah; Oak Ridge National Laboratory
  • Christiane Alvarez; Oak Ridge National Laboratory
  • David Kainer; Oak Ridge National Laboratory
  • Omar Demerdash; Oak Ridge National Laboratory
  • B Kirtley Amos; University of Kentucky
  • Armin Geiger; University of Tennessee Knoxville
  • Daniel Jacobson; Oak Ridge National Laboratory
Preprint Dans Anglais | bioRxiv | ID: ppbiorxiv-028712
ABSTRACT
Using a Systems Biology approach, we integrated genomic, transcriptomic, proteomic, and molecular structure information to provide a holistic understanding of the COVID-19 pandemic. The expression data analysis of the Renin Angiotensin System indicates mild nasal, oral or throat infections are likely and that the gastrointestinal tissues are a common primary target of SARS-CoV-2. Extreme symptoms in the lower respiratory system likely result from a secondary-infection possibly by a comorbidity-driven upregulation of ACE2 in the lung. The remarkable differences in expression of other RAS elements, the elimination of macrophages and the activation of cytokines in COVID-19 bronchoalveolar samples suggest that a functional immune deficiency is a critical outcome of COVID-19. We posit that using a non-respiratory system as a major pathway of infection is likely determining the unprecedented global spread of this coronavirus. One Sentence SummaryA Systems Approach Indicates Non-respiratory Pathways of Infection as Key for the COVID-19 Pandemic
Texte intégral: Disponible Collection: Preprints Base de données: bioRxiv langue: Anglais Année: 2020 Type de document: Preprint

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Texte intégral: Disponible Collection: Preprints Base de données: bioRxiv langue: Anglais Année: 2020 Type de document: Preprint