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The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the Spike protein
Paola Cristina Resende; Felipe Gomes Naveca; Roberto Dias Lins; Filipe Zimmer Dezordi; Matheus V. F. Ferraz; Emerson G. Moreira; Danilo F. Coelho; Fernando Couto Motta; Anna Carolina Dias Paixao; Luciana Appolinario; Renata Serrano Lopes; Ana Carolina da Fonseca Mendonca; Alice Sampaio Barreto da Rocha; Valdinete Nascimento; Victor Souza; George Silva; Fernanda Nascimento; Lidio Goncalves Lima Neto; Fabiano Vieira da Silva; Irina Riediger; Maria do Carmo Debur; Anderson Brandao Leite; Tirza Mattos; Cristiano Fernandes da Costa; Felicidade Mota Pereira; Cliomar Alves dos Santos; Darcita Buerger Rovaris; Sandra Bianchini Fernandes; Adriano Abbud; Claudio Sacchi; Ricardo Khouri; Andre Felipe Leal Bernardes; Edson Delatorre; Tiago Graf; Marilda Mendonca Siqueira; Gonzalo Bello; Gabriel Luz Wallau; - Fiocruz COVID-19 Genomic Surveillance Network.
  • Paola Cristina Resende; Oswaldo Cruz Institute
  • Felipe Gomes Naveca; Laboratorio de Ecologia de Doencas Transmissiveis na Amazonia (EDTA), Instituto Leonidas e Maria Deane, FIOCRUZ-Amazonas
  • Roberto Dias Lins; Department of Virology, Instituto Aggeu Magalhaes, FIOCRUZ-Pernambuco
  • Filipe Zimmer Dezordi; Departamento de Entomologia e Nucleo de Bioinformatica, Instituto Aggeu Magalhaes, FIOCRUZ-Pernambuco, Brazil
  • Matheus V. F. Ferraz; Department of Virology, Instituto Aggeu Magalhaes, FIOCRUZ-Pernambuco
  • Emerson G. Moreira; Department of Virology, Instituto Aggeu Magalhaes, FIOCRUZ-Pernambuco
  • Danilo F. Coelho; Department of Fundamental Chemistry, Federal University of Pernambuco
  • Fernando Couto Motta; Laboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz
  • Anna Carolina Dias Paixao; Laboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz
  • Luciana Appolinario; Laboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz
  • Renata Serrano Lopes; Laboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz
  • Ana Carolina da Fonseca Mendonca; Laboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz
  • Alice Sampaio Barreto da Rocha; Laboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz
  • Valdinete Nascimento; Laboratorio de Ecologia de Doencas Transmissiveis na Amazonia (EDTA), Instituto Leonidas e Maria Deane, FIOCRUZ-Amazonas
  • Victor Souza; Laboratorio de Ecologia de Doencas Transmissiveis na Amazonia (EDTA), Instituto Leonidas e Maria Deane, FIOCRUZ-Amazonas
  • George Silva; Laboratorio de Ecologia de Doencas Transmissiveis na Amazonia (EDTA), Instituto Leonidas e Maria Deane, FIOCRUZ-Amazonas
  • Fernanda Nascimento; Laboratorio de Ecologia de Doencas Transmissiveis na Amazonia (EDTA), Instituto Leonidas e Maria Deane, FIOCRUZ-Amazonas
  • Lidio Goncalves Lima Neto; Laboratorio Central de Saude Publica do Estado do Maranhao (LACEN-MA)
  • Fabiano Vieira da Silva; Laboratorio Central de Saude Publica do Maranhao (LACEN-MA)
  • Irina Riediger; Laboratorio Central de Saude Publica do Estado do Parana (LACEN-PR)
  • Maria do Carmo Debur; Laboratorio Central de Saude Publica do Estado do Parana (LACEN-PR)
  • Anderson Brandao Leite; Laboratorio Central de Saude Publica do Estado do Alagoas (LACEN-AL)
  • Tirza Mattos; Laboratorio Central de Saude Publica do Amazonas (LACEN-AM)
  • Cristiano Fernandes da Costa; Fundacao de Vigilancia em Saude do Amazonas
  • Felicidade Mota Pereira; Laboratorio Central de Saude Publica do Estado da Bahia (LACEN-BA)
  • Cliomar Alves dos Santos; Laboratorio Central de Saude Publica do Estado de Sergipe (LACEN-SE)
  • Darcita Buerger Rovaris; Laboratorio Central de Saude Publica do Estado de Santa Catarina (LACEN-SC)
  • Sandra Bianchini Fernandes; Laboratorio Central de Saude Publica do Estado de Santa Catarina (LACEN-SC)
  • Adriano Abbud; Instituto Adolfo Lutz
  • Claudio Sacchi; Instituto Adolfo Lutz
  • Ricardo Khouri; Laboratorio de Enfermidades Infecciosas Transmitidas por Vetores, Instituto Goncalo Moniz, FIOCRUZ-Bahia
  • Andre Felipe Leal Bernardes; Laboratorio Central de Saude Publica do Estado de Minas Gerais (LACEN-MG)
  • Edson Delatorre; Departamento de Biologia. Centro de Ciencias Exatas, Naturais e da Saude, Universidade Federal do Espirito Santo
  • Tiago Graf; Plataforma de Vigilancia Molecular, Instituto Goncalo Moniz, FIOCRUZ-Bahia
  • Marilda Mendonca Siqueira; Laboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz
  • Gonzalo Bello; Laboratorio de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz
  • Gabriel Luz Wallau; Oswaldo Cruz Foundation
  • - Fiocruz COVID-19 Genomic Surveillance Network;
Preprint Dans Anglais | medRxiv | ID: ppmedrxiv-21253946
Journal article
A scientific journal published article is available and is probably based on this preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
Mutations at both the receptor-binding domain (RBD) and the amino (N)-terminal domain (NTD) of the SARS-CoV-2 Spike (S) glycoprotein can alter its antigenicity and promote immune escape. We identified that SARS-CoV-2 lineages circulating in Brazil with mutations of concern in the RBD independently acquired convergent deletions and insertions in the NTD of the S protein, which altered the NTD antigenic-supersite and other predicted epitopes at this region. These findings support that the ongoing widespread transmission of SARS-CoV-2 in Brazil is generating new viral lineages that might be more resistant to neutralization than parental variants of concern.
Texte intégral: Disponible Collection: Preprints Base de données: medRxiv Type d'étude: Étude pronostique Les sujets: Variantes langue: Anglais Année: 2021 Type de document: Preprint

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Texte intégral: Disponible Collection: Preprints Base de données: medRxiv Type d'étude: Étude pronostique Les sujets: Variantes langue: Anglais Année: 2021 Type de document: Preprint