Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Nat Med
; 26(6): 842-844, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1900503
ABSTRACT
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
/
Infecções por Coronavirus
/
Análise de Célula Única
/
Betacoronavirus
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Nat Med
Assunto da revista:
Biologia Molecular
/
Medicina
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
S41591-020-0901-9
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