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Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2-Infected Macaques.
Koo, Bon-Sang; Oh, Hanseul; Kim, Green; Hwang, Eun-Ha; Jung, Hoyin; Lee, Youngjeon; Kang, Philyong; Park, Jae-Hak; Ryu, Choong-Min; Hong, Jung Joo.
  • Koo BS; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Oh H; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Kim G; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Hwang EH; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Jung H; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Lee Y; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Kang P; Futuristic Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Park JH; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
  • Ryu CM; Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
  • Hong JJ; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
J Infect Dis ; 222(10): 1596-1600, 2020 10 13.
Artigo em Inglês | MEDLINE | ID: covidwho-693639
ABSTRACT
Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Doenças Pulmonares Intersticiais / Infecções por Coronavirus / Modelos Animais de Doenças / Betacoronavirus / Linfopenia / Doenças dos Macacos Tópicos: Covid persistente Limite: Animais Idioma: Inglês Revista: J Infect Dis Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Doenças Pulmonares Intersticiais / Infecções por Coronavirus / Modelos Animais de Doenças / Betacoronavirus / Linfopenia / Doenças dos Macacos Tópicos: Covid persistente Limite: Animais Idioma: Inglês Revista: J Infect Dis Ano de publicação: 2020 Tipo de documento: Artigo