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The imprinting effect of COVID-19 vaccines: an expected selection bias in observational studies (preprint)
medrxiv; 2022.
Preprint em Inglês | medRxiv | ID: ppzbmed-10.1101.2022.11.30.22282923
ABSTRACT
Findings of recent observational studies have been interpreted as supporting immune imprinting of COVID-19 vaccines. In this work, we clarify that the current discussion can be mapped to an attempt to estimate the direct effect of vaccine boosters on SARS-CoV-2 reinfections, and that such direct effect cannot be correctly estimated with observational data. We conclude that recent observational estimates regarding immune imprinting are fundamentally biased, and that the increased risk of reinfection in individuals vaccinated with a vaccine booster compared to no booster is expected even if the immune imprinting hypothesis is false. We use graphical methods (directed acyclic graphs), data simulations and analysis of real-life data to illustrate the mechanism and magnitude of this bias.
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Assunto principal: COVID-19 Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint

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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Assunto principal: COVID-19 Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint